Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003633707> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2003633707 endingPage "91a" @default.
- W2003633707 startingPage "91a" @default.
- W2003633707 abstract "We have collected several observations of threshold events in the interactions of antimicrobial peptides (AMPs) with model membranes. These, however, usually occur very close to full membrane coverage. Because such events are frequently disruptive (lysis, pore formation, charge neutralization) we hypothesize a link between these and the antibacterial activity of the peptides. We then establish a mathematical relationship between the biophysical properties of AMPs and threshold events in the bacterial membrane, and demonstrate that high membrane coverage is not only physiologically plausible but also a likely requirement for AMP activity. In agreement, a co-occurrence of bacterial death and surface charge neutralization was observed using zeta-potential measurements of E. coli suspensions treated with the AMP BP100:View Large Image | View Hi-Res Image | Download PowerPoint SlideOur model further allows the prediction of biologically-observed AMP activities (the minimum inhibitory concentrations) from biophysical parameters of peptide-membrane interaction. This approach successfully predicted the activities of two different AMPs against a set of susceptible strains.[1] M.N. Melo, R. Ferre and M.A.R.B. Castanho, Nature. Rev. Microbiol, 2009, 7:245[2] C.S. Alves, M.N. Melo, et al., J. Biol. Chem., 2010, 285:27536.[3] R. Ferre∗, M.N. Melo∗, et al., Biophys. J., 2009, 96:1815." @default.
- W2003633707 created "2016-06-24" @default.
- W2003633707 creator A5013069107 @default.
- W2003633707 creator A5028135857 @default.
- W2003633707 creator A5079018843 @default.
- W2003633707 creator A5082419958 @default.
- W2003633707 date "2012-01-01" @default.
- W2003633707 modified "2023-09-29" @default.
- W2003633707 title "Relating Molecular-Level Events with Bacterial Killing by Antimicrobial Peptides" @default.
- W2003633707 doi "https://doi.org/10.1016/j.bpj.2011.11.518" @default.
- W2003633707 hasPublicationYear "2012" @default.
- W2003633707 type Work @default.
- W2003633707 sameAs 2003633707 @default.
- W2003633707 citedByCount "0" @default.
- W2003633707 crossrefType "journal-article" @default.
- W2003633707 hasAuthorship W2003633707A5013069107 @default.
- W2003633707 hasAuthorship W2003633707A5028135857 @default.
- W2003633707 hasAuthorship W2003633707A5079018843 @default.
- W2003633707 hasAuthorship W2003633707A5082419958 @default.
- W2003633707 hasBestOaLocation W20036337071 @default.
- W2003633707 hasConcept C121332964 @default.
- W2003633707 hasConcept C12554922 @default.
- W2003633707 hasConcept C14086860 @default.
- W2003633707 hasConcept C155672457 @default.
- W2003633707 hasConcept C159654299 @default.
- W2003633707 hasConcept C185592680 @default.
- W2003633707 hasConcept C2779281246 @default.
- W2003633707 hasConcept C41625074 @default.
- W2003633707 hasConcept C4937899 @default.
- W2003633707 hasConcept C540938839 @default.
- W2003633707 hasConcept C54355233 @default.
- W2003633707 hasConcept C55493867 @default.
- W2003633707 hasConcept C57409179 @default.
- W2003633707 hasConcept C62520636 @default.
- W2003633707 hasConcept C86181022 @default.
- W2003633707 hasConcept C86803240 @default.
- W2003633707 hasConcept C89423630 @default.
- W2003633707 hasConceptScore W2003633707C121332964 @default.
- W2003633707 hasConceptScore W2003633707C12554922 @default.
- W2003633707 hasConceptScore W2003633707C14086860 @default.
- W2003633707 hasConceptScore W2003633707C155672457 @default.
- W2003633707 hasConceptScore W2003633707C159654299 @default.
- W2003633707 hasConceptScore W2003633707C185592680 @default.
- W2003633707 hasConceptScore W2003633707C2779281246 @default.
- W2003633707 hasConceptScore W2003633707C41625074 @default.
- W2003633707 hasConceptScore W2003633707C4937899 @default.
- W2003633707 hasConceptScore W2003633707C540938839 @default.
- W2003633707 hasConceptScore W2003633707C54355233 @default.
- W2003633707 hasConceptScore W2003633707C55493867 @default.
- W2003633707 hasConceptScore W2003633707C57409179 @default.
- W2003633707 hasConceptScore W2003633707C62520636 @default.
- W2003633707 hasConceptScore W2003633707C86181022 @default.
- W2003633707 hasConceptScore W2003633707C86803240 @default.
- W2003633707 hasConceptScore W2003633707C89423630 @default.
- W2003633707 hasIssue "3" @default.
- W2003633707 hasLocation W20036337071 @default.
- W2003633707 hasOpenAccess W2003633707 @default.
- W2003633707 hasPrimaryLocation W20036337071 @default.
- W2003633707 hasRelatedWork W1953489421 @default.
- W2003633707 hasRelatedWork W1983499486 @default.
- W2003633707 hasRelatedWork W1993417736 @default.
- W2003633707 hasRelatedWork W2004373761 @default.
- W2003633707 hasRelatedWork W2017975154 @default.
- W2003633707 hasRelatedWork W2030579337 @default.
- W2003633707 hasRelatedWork W2046867306 @default.
- W2003633707 hasRelatedWork W2082436428 @default.
- W2003633707 hasRelatedWork W2084246486 @default.
- W2003633707 hasRelatedWork W2126044069 @default.
- W2003633707 hasRelatedWork W2155622354 @default.
- W2003633707 hasRelatedWork W2324215686 @default.
- W2003633707 hasRelatedWork W2499035467 @default.
- W2003633707 hasRelatedWork W2519250971 @default.
- W2003633707 hasRelatedWork W2588028078 @default.
- W2003633707 hasRelatedWork W2621138218 @default.
- W2003633707 hasRelatedWork W2963865909 @default.
- W2003633707 hasRelatedWork W3049415191 @default.
- W2003633707 hasRelatedWork W3109796473 @default.
- W2003633707 hasRelatedWork W639919736 @default.
- W2003633707 hasVolume "102" @default.
- W2003633707 isParatext "false" @default.
- W2003633707 isRetracted "false" @default.
- W2003633707 magId "2003633707" @default.
- W2003633707 workType "article" @default.