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• W2003635400 startingPage "397" @default.
• W2003635400 abstract "The direct thrombin inhibitor, ximelagatran, and its active form, melagatran (X/M), have been compared against conventional anticoagulant therapy (CAT) in many clinical settings. Their risk–benefit profile drove large debate until withdrawal by the manufacturer. A systematic review of all published randomized trials has been performed and a meta-analysis of randomised controlled trial (RCT) of X/M versus CAT. Major medical databases were searched for RCTs. Major adverse events (MAE: all cause death, nonfatal myocardial infarction, nonfatal thromboembolic stroke, pulmonary embolism), major bleeds (MB), minor bleeds and the rate of hepatotoxicity (HT) were compared. In terms of efficacy, X/M was at least as effective as, or even superior to, CAT. In terms of safety, the overall risk of MAE, MB, minor bleeds and HT was not significantly different for X/M compared with CAT. According to individual clinical settings, X/M was associated with a lower risk of MB but a prohibitive higher risk of HT in those clinical settings requiring prolonged treatment." @default.
• W2003635400 created "2016-06-24" @default.
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• W2003635400 date "2007-07-01" @default.
• W2003635400 modified "2023-10-03" @default.
• W2003635400 title "The direct thrombin inhibitor ximelagatran/melagatran: a systematic review on clinical applications and an evidence based assessment of risk benefit profile" @default.
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• W2003635400 doi "https://doi.org/10.1517/14740338.6.4.397" @default.
• W2003635400 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17688383" @default.
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