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• W2003641509 abstract "BackgroundDengue shock syndrome is the most severe from of dengue haemorrhagic fever, one of the leading causes of death in children. Observational studies have suggested corticosteroids may benefit people with dengue shock syndrome.ObjectivesTo compare corticosteroids with placebo or no corticosteroids for treating dengue shock syndrome.Search strategyWe searched the Cochrane Infectious Disease Group Specialized Register (January 2006), CENTRAL (The Cochrane Library 2005, Issue 4), MEDLINE (1966 to January 2006), EMBASE, (1974 to January 2006), LILACS (1982 to January 2006), and reference lists. We also contacted researchers.Selection criteriaRandomized and quasi-randomized controlled trials comparing corticosteroids with no corticosteroids or placebo in people diagnosed with dengue shock syndrome.Data collection and analysisTwo authors independently applied the inclusion criteria, extracted data, and assessed methodological quality. We calculated the relative risk (RR) for dichotomous data and weighted mean difference for continuous data, and presented them with 95% confidence intervals (CI).Main resultsFour trials involving 284 participants met the inclusion criteria. Corticosteroids were no more effective than placebo or no treatment for reducing the number of deaths (RR 0.68, 95% CI 0.42 to 1.11; 284 participants, 4 trials), the need for blood transfusion (RR 1.08, 0.52 to 2.24; 89 participants, 2 trials), or the number of serious complications (convulsions and pulmonary haemorrhage) as reported in one trial (63 participants).Authors' conclusionsThere is insufficient evidence to justify the use of corticosteroids in managing dengue shock syndrome. As corticosteroids can potentially do harm, clinicians should not use them unless they are participating in a randomized controlled trial comparing corticosteroids with placebo.Plain language summaryNo good evidence that corticosteroids are helpful in dengue shock syndromeThe dengue virus is transmitted by mosquitoes and can cause either a mild illness with fever or a more severe illness with fever and bleeding (dengue haemorrhagic fever). The bleeding is generally seen as tiny red spots on the skin but can occasionally be more severe affecting the nose, gums, and gut. In its most severe form it can cause shock, collapse, and sometimes death (dengue shock syndrome). The current treatment for dengue shock syndrome is to give fluids directly into the bloodstream, but corticosteroids have been suggested as drugs that may help due to their anti-inflammatory properties. This review of trials found only four small trials (with 284 participants) that were not of good quality and which showed no benefit overall. Further trials would be needed before this drug were used in these patients, as there is the potential for adverse effects due to the drugs' properties of suppressing the immune system and potentially leaving people open to other infections." @default.
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• W2003641509 date "2007-01-01" @default.
• W2003641509 modified "2023-09-25" @default.
• W2003641509 title "Cochrane review: Corticosteroids for treating dengue shock syndrome" @default.
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• W2003641509 doi "https://doi.org/10.1002/ebch.165" @default.
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