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- W2003641573 abstract "ObjectiveThe complement system plays a central role in the defense against invading pathogens, and its activation involves the release of potent pro-inflammatory mediators such as anaphylatoxins C3a, C4a and C5a. The aim of this study was to determine if there were differences between maternal plasma anaphylatoxin concentrations in patients with term and preterm parturition.Study designPlasma samples were obtained from 232 pregnant women in the following groups: 1) term not in labor (n = 70); 2) term in labor (n = 60); and 3) preterm labor (PTL) (n = 102). Women with PTL were further classified into: a) term delivery (n = 24); b) preterm delivery (PTD) without intra-amniotic infection (IAI) (n = 62); and c) those with IAI (n = 16). Concentrations of C3a, C4a and C5a were determined by ELISA. Non-parametric statistics were used for analysis.ResultsTabled 1C3aC4aC5aTerm not in labor2101929913.91509-28835425-1354010.3-18.5Term in labor1932700310.01467-29424090-134476.9-13.4PTL with term delivery2778834915.21358-39792570-129879.2-20.4PTD without IAI2252867313.31627-28704725-137229.4-17.2PTD with IAI3275806221.42196-52274478-1501018.6-26.2Values expressed as median and 25th-75th quartiles (ng/mL). P values are in the text. Open table in a new tab ConclusionThe maternal plasma concentration of the anaphylatoxin C5a is increased in women with PTL and IAI, but not in spontaneous labor at term. ObjectiveThe complement system plays a central role in the defense against invading pathogens, and its activation involves the release of potent pro-inflammatory mediators such as anaphylatoxins C3a, C4a and C5a. The aim of this study was to determine if there were differences between maternal plasma anaphylatoxin concentrations in patients with term and preterm parturition. The complement system plays a central role in the defense against invading pathogens, and its activation involves the release of potent pro-inflammatory mediators such as anaphylatoxins C3a, C4a and C5a. The aim of this study was to determine if there were differences between maternal plasma anaphylatoxin concentrations in patients with term and preterm parturition. Study designPlasma samples were obtained from 232 pregnant women in the following groups: 1) term not in labor (n = 70); 2) term in labor (n = 60); and 3) preterm labor (PTL) (n = 102). Women with PTL were further classified into: a) term delivery (n = 24); b) preterm delivery (PTD) without intra-amniotic infection (IAI) (n = 62); and c) those with IAI (n = 16). Concentrations of C3a, C4a and C5a were determined by ELISA. Non-parametric statistics were used for analysis. Plasma samples were obtained from 232 pregnant women in the following groups: 1) term not in labor (n = 70); 2) term in labor (n = 60); and 3) preterm labor (PTL) (n = 102). Women with PTL were further classified into: a) term delivery (n = 24); b) preterm delivery (PTD) without intra-amniotic infection (IAI) (n = 62); and c) those with IAI (n = 16). Concentrations of C3a, C4a and C5a were determined by ELISA. Non-parametric statistics were used for analysis. ResultsTabled 1C3aC4aC5aTerm not in labor2101929913.91509-28835425-1354010.3-18.5Term in labor1932700310.01467-29424090-134476.9-13.4PTL with term delivery2778834915.21358-39792570-129879.2-20.4PTD without IAI2252867313.31627-28704725-137229.4-17.2PTD with IAI3275806221.42196-52274478-1501018.6-26.2Values expressed as median and 25th-75th quartiles (ng/mL). P values are in the text. Open table in a new tab Values expressed as median and 25th-75th quartiles (ng/mL). P values are in the text. ConclusionThe maternal plasma concentration of the anaphylatoxin C5a is increased in women with PTL and IAI, but not in spontaneous labor at term. The maternal plasma concentration of the anaphylatoxin C5a is increased in women with PTL and IAI, but not in spontaneous labor at term." @default.
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- W2003641573 title "Anaphylatoxins in preterm and term labor" @default.
- W2003641573 doi "https://doi.org/10.1016/j.ajog.2004.10.192" @default.
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