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- W2003642624 abstract "Nucleic acid sensing-TLRs recognize pathogen-derived nucleic acids (NAs) and induce anti-microbial immune responses. NA-sensing TLRs are reported to have a risk of mistakenly responding to self-derived NAs and causing a variety of autoimmune diseases. To warrant innate immune responses without detrimental inflammation, NA-sensing TLRs need to be tightly controlled in multiple aspects including expression and downstream signaling pathways. Along this line, TLR7 vs 9 balance has emerged as a new mechanism that controls activation of RNA-sensor TLR7. In this review, we discuss mechanisms controlling NA-sensing TLRs and autoimmune diseases as consequences of the dysregulated control mechanisms." @default.
- W2003642624 created "2016-06-24" @default.
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- W2003642624 date "2012-08-01" @default.
- W2003642624 modified "2023-09-27" @default.
- W2003642624 title "Controlling systems of nucleic acid sensing-TLRs restrict homeostatic inflammation" @default.
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- W2003642624 doi "https://doi.org/10.1016/j.yexcr.2012.03.032" @default.
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