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- W2003643704 abstract "To the Editor:The PROUD trial, which is registered in Germany and is examining the effects of suture type on surgical site infection (SSI), was published shortly before our systematic literature review [1,2]. The methods met the eligibility criteria of our review protocol. An extraction of literature databases returned no other new relevant study. The meta-analysis was updated with the 16th trial (Fig. 1). It presented a relative weight of 17.1% and did not introduce significant publication bias (Egger regression p=0.085) or heterogeneity (Q-test p=0.112). The results were consistent with those of the 15-trial meta-analysis. The random-effects risk ratio (RR) was 0.71 with a 95% confidence interval (CI) of 0.58–0.87 (p<0.0012). Sensitivity analysis confirmed the robustness of the results. The three trials with the highest relative weight after the PROUD trials had to be removed jointly for the pooled RR to become non-significant: 0.79, 95% CI 0.79–1.01, p<0.057 [3–5]. That trial considerably strengthened the polydioxanone subgroup but had little effect on the results of covariable analysis.FIG. 1.Random-effects pooled relative risk of surgical site infection in 16 randomized controlled trials of different suture materials.The data that could be pooled from the 16 trials so far did not enable an explanation of the large variations in RR across trials. Moreover, publications did not describe the treatments and outcomes of the SSIs systematically, so the impact of suture type on burden-of-illness could not be estimated.Leveraging source data of current trials could be attempted through a collaborative database of individual data that should include treatments and outcomes of SSIs that could be retrieved from patient charts. Individual level meta-analysis would increase the power to detect covariables that explain the large differences in RRs across trials and would also enable estimation of burden-of-illness.If this approach proves to yield more knowledge from current trials, ongoing and future trials could consider participating in this collaborative effort in order to leverage the contribution of their own findings to the overall evidence." @default.
- W2003643704 created "2016-06-24" @default.
- W2003643704 creator A5024590579 @default.
- W2003643704 date "2014-12-01" @default.
- W2003643704 modified "2023-09-25" @default.
- W2003643704 title "Systematic Literature Review Update of the PROUD Trial: Potential Usefulness of a Collaborative Database" @default.
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- W2003643704 doi "https://doi.org/10.1089/sur.2014.129" @default.
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