FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003643706> ?p ?o ?g. }

• W2003643706 endingPage "17" @default.
• W2003643706 startingPage "9" @default.
• W2003643706 abstract "To evaluate the relevance of fragile histidine triad (FHIT) status in relation to drug treatment, we analyzed the sensitivity of the Fhit-negative non-small cell lung cancer (NSCLC) cell line NCI-H460 to different drugs, after treatment with an adenoviral vector expressing the FHITtransgene. Expression of Fhit resulted in reduced sensitivity to etoposide, doxorubicin, and topotecan. This feature was associated with Fhit-induced downregulation of DNA topoisomerases I and II. In contrast, expression of Fhit did not modulate sensitivity to Taxol, but produced a slight increase in sensitivity to cisplatin, as shown by colony-forming assays. Analysis of apoptosis revealed that, after cisplatin exposure, the number of apoptotic cells was two-fold higher in Fhitexpressing H460 cells. Moreover, it appeared that wildtype p53 was required for sensitization to cisplatin because the effect was marginal in A549 and Calu-1 cells, where the p53 pathway is altered and simultaneous restoration of p53 and Fhit in Calu-1 cells increased cisplatin sensitivity. Fhit could also partially restore sensitivity to cisplatin in Bcl-2- and BCl-xL-overexpressing H460 cells that are normally resistant to this drug. Our results support the possible relevance of FHIT in cisplatin-based chemotherapy as well as in the reversal of drug resistance in NSCLC." @default.
• W2003643706 created "2016-06-24" @default.
• W2003643706 creator A5026088340 @default.
• W2003643706 creator A5048820442 @default.
• W2003643706 creator A5050558965 @default.
• W2003643706 creator A5064380274 @default.
• W2003643706 creator A5071824275 @default.
• W2003643706 date "2006-01-01" @default.
• W2003643706 modified "2023-09-27" @default.
• W2003643706 title "Increased Sensitivity to Cisplatin in Non-Small Cell Lung Cancer Cell Lines after FHIT Gene Transfer" @default.
• W2003643706 cites W130569595 @default.
• W2003643706 cites W1595351866 @default.
• W2003643706 cites W1595815978 @default.
• W2003643706 cites W1762040713 @default.
• W2003643706 cites W1781814254 @default.
• W2003643706 cites W1965925888 @default.
• W2003643706 cites W1978777859 @default.
• W2003643706 cites W1988086962 @default.
• W2003643706 cites W2018862418 @default.
• W2003643706 cites W2020050900 @default.
• W2003643706 cites W2024211667 @default.
• W2003643706 cites W2024411346 @default.
• W2003643706 cites W2037139573 @default.
• W2003643706 cites W2037837430 @default.
• W2003643706 cites W2051057020 @default.
• W2003643706 cites W2058554860 @default.
• W2003643706 cites W2072252062 @default.
• W2003643706 cites W2093598063 @default.
• W2003643706 cites W2109689528 @default.
• W2003643706 cites W2115371904 @default.
• W2003643706 cites W2127264026 @default.
• W2003643706 cites W2130496537 @default.
• W2003643706 cites W2134864870 @default.
• W2003643706 cites W2138759116 @default.
• W2003643706 cites W2139333680 @default.
• W2003643706 cites W2140950117 @default.
• W2003643706 cites W2158157639 @default.
• W2003643706 cites W2399288709 @default.
• W2003643706 cites W4235345077 @default.
• W2003643706 cites W4322700005 @default.
• W2003643706 doi "https://doi.org/10.1593/neo.05517" @default.
• W2003643706 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1584285" @default.
• W2003643706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16533421" @default.
• W2003643706 hasPublicationYear "2006" @default.
• W2003643706 type Work @default.
• W2003643706 sameAs 2003643706 @default.
• W2003643706 citedByCount "30" @default.
• W2003643706 countsByYear W20036437062012 @default.
• W2003643706 countsByYear W20036437062013 @default.
• W2003643706 countsByYear W20036437062014 @default.
• W2003643706 countsByYear W20036437062015 @default.
• W2003643706 countsByYear W20036437062017 @default.
• W2003643706 countsByYear W20036437062018 @default.
• W2003643706 countsByYear W20036437062019 @default.
• W2003643706 countsByYear W20036437062020 @default.
• W2003643706 countsByYear W20036437062021 @default.
• W2003643706 countsByYear W20036437062022 @default.
• W2003643706 countsByYear W20036437062023 @default.
• W2003643706 crossrefType "journal-article" @default.
• W2003643706 hasAuthorship W2003643706A5026088340 @default.
• W2003643706 hasAuthorship W2003643706A5048820442 @default.
• W2003643706 hasAuthorship W2003643706A5050558965 @default.
• W2003643706 hasAuthorship W2003643706A5064380274 @default.
• W2003643706 hasAuthorship W2003643706A5071824275 @default.
• W2003643706 hasBestOaLocation W20036437061 @default.
• W2003643706 hasConcept C121608353 @default.
• W2003643706 hasConcept C1491633281 @default.
• W2003643706 hasConcept C153911025 @default.
• W2003643706 hasConcept C190283241 @default.
• W2003643706 hasConcept C2776694085 @default.
• W2003643706 hasConcept C2778119113 @default.
• W2003643706 hasConcept C2778239845 @default.
• W2003643706 hasConcept C2778264664 @default.
• W2003643706 hasConcept C2780646079 @default.
• W2003643706 hasConcept C502942594 @default.
• W2003643706 hasConcept C54355233 @default.
• W2003643706 hasConcept C55493867 @default.
• W2003643706 hasConcept C555283112 @default.
• W2003643706 hasConcept C81885089 @default.
• W2003643706 hasConcept C86803240 @default.
• W2003643706 hasConceptScore W2003643706C121608353 @default.
• W2003643706 hasConceptScore W2003643706C1491633281 @default.
• W2003643706 hasConceptScore W2003643706C153911025 @default.
• W2003643706 hasConceptScore W2003643706C190283241 @default.
• W2003643706 hasConceptScore W2003643706C2776694085 @default.
• W2003643706 hasConceptScore W2003643706C2778119113 @default.
• W2003643706 hasConceptScore W2003643706C2778239845 @default.
• W2003643706 hasConceptScore W2003643706C2778264664 @default.
• W2003643706 hasConceptScore W2003643706C2780646079 @default.
• W2003643706 hasConceptScore W2003643706C502942594 @default.
• W2003643706 hasConceptScore W2003643706C54355233 @default.
• W2003643706 hasConceptScore W2003643706C55493867 @default.
• W2003643706 hasConceptScore W2003643706C555283112 @default.
• W2003643706 hasConceptScore W2003643706C81885089 @default.
• W2003643706 hasConceptScore W2003643706C86803240 @default.
• W2003643706 hasIssue "1" @default.
• W2003643706 hasLocation W20036437061 @default.
• W2003643706 hasLocation W20036437062 @default.

• next