FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003643802> ?p ?o ?g. }

• W2003643802 endingPage "675" @default.
• W2003643802 startingPage "665" @default.
• W2003643802 abstract "Poliovirus VPg is a 22 amino acid residue peptide that serves as the protein primer for replication of the viral RNA genome. VPg is known to bind directly to the viral RNA-dependent RNA polymerase, 3D, for covalent uridylylation, yielding mono and di-uridylylated products, VPg-pU and VPg-pUpU, which are subsequently elongated. To model the docking of the VPg substrate to a putative VPg-binding site on the 3D polymerase molecule, we performed a variety of structure-based computations followed by experimental verification. First, potential VPg folded structures were identified, yielding a suite of predicted beta-hairpin structures. These putative VPg structures were then docked to the region of the polymerase implicated by genetic experiments to bind VPg, using grid-based and fragment-based methods. Residues in VPg predicted to affect binding were identified through molecular dynamics simulations, and their effects on the 3D-VPg interaction were tested computationally and biochemically. Experiments with mutant VPg and mutant polymerase molecules confirmed the predicted binding site for VPg on the back side of the polymerase molecule during the uridylylation reaction, opposite to that predicted to bind elongating RNA primers." @default.
• W2003643802 created "2016-06-24" @default.
• W2003643802 creator A5003514537 @default.
• W2003643802 creator A5005581368 @default.
• W2003643802 creator A5008054535 @default.
• W2003643802 creator A5050965460 @default.
• W2003643802 creator A5067068683 @default.
• W2003643802 creator A5073092630 @default.
• W2003643802 creator A5091769486 @default.
• W2003643802 date "2006-03-01" @default.
• W2003643802 modified "2023-09-26" @default.
• W2003643802 title "Nucleotide Channel of RNA-dependent RNA Polymerase used for Intermolecular Uridylylation of Protein Primer" @default.
• W2003643802 cites W1567952953 @default.
• W2003643802 cites W1678031494 @default.
• W2003643802 cites W1967154222 @default.
• W2003643802 cites W1967798978 @default.
• W2003643802 cites W1971403013 @default.
• W2003643802 cites W1973711348 @default.
• W2003643802 cites W1980651773 @default.
• W2003643802 cites W1981021420 @default.
• W2003643802 cites W2015403140 @default.
• W2003643802 cites W2018573779 @default.
• W2003643802 cites W2018619488 @default.
• W2003643802 cites W2022618835 @default.
• W2003643802 cites W2023355401 @default.
• W2003643802 cites W2031926002 @default.
• W2003643802 cites W2038910312 @default.
• W2003643802 cites W2065711381 @default.
• W2003643802 cites W2101716268 @default.
• W2003643802 cites W2110451367 @default.
• W2003643802 cites W2110670926 @default.
• W2003643802 cites W2114460086 @default.
• W2003643802 cites W2114779636 @default.
• W2003643802 cites W2118848130 @default.
• W2003643802 cites W2123768693 @default.
• W2003643802 cites W2130479394 @default.
• W2003643802 cites W2133842820 @default.
• W2003643802 cites W2139614856 @default.
• W2003643802 cites W2139911700 @default.
• W2003643802 cites W2154106236 @default.
• W2003643802 cites W2165639777 @default.
• W2003643802 cites W2171460607 @default.
• W2003643802 doi "https://doi.org/10.1016/j.jmb.2005.12.044" @default.
• W2003643802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16427083" @default.
• W2003643802 hasPublicationYear "2006" @default.
• W2003643802 type Work @default.
• W2003643802 sameAs 2003643802 @default.
• W2003643802 citedByCount "27" @default.
• W2003643802 countsByYear W20036438022012 @default.
• W2003643802 countsByYear W20036438022013 @default.
• W2003643802 countsByYear W20036438022014 @default.
• W2003643802 countsByYear W20036438022015 @default.
• W2003643802 countsByYear W20036438022020 @default.
• W2003643802 countsByYear W20036438022021 @default.
• W2003643802 crossrefType "journal-article" @default.
• W2003643802 hasAuthorship W2003643802A5003514537 @default.
• W2003643802 hasAuthorship W2003643802A5005581368 @default.
• W2003643802 hasAuthorship W2003643802A5008054535 @default.
• W2003643802 hasAuthorship W2003643802A5050965460 @default.
• W2003643802 hasAuthorship W2003643802A5067068683 @default.
• W2003643802 hasAuthorship W2003643802A5073092630 @default.
• W2003643802 hasAuthorship W2003643802A5091769486 @default.
• W2003643802 hasBestOaLocation W20036438022 @default.
• W2003643802 hasConcept C104317684 @default.
• W2003643802 hasConcept C107824862 @default.
• W2003643802 hasConcept C143065580 @default.
• W2003643802 hasConcept C153911025 @default.
• W2003643802 hasConcept C178790620 @default.
• W2003643802 hasConcept C181199279 @default.
• W2003643802 hasConcept C185592680 @default.
• W2003643802 hasConcept C2776449523 @default.
• W2003643802 hasConcept C2777563447 @default.
• W2003643802 hasConcept C41258723 @default.
• W2003643802 hasConcept C55493867 @default.
• W2003643802 hasConcept C67705224 @default.
• W2003643802 hasConcept C82381507 @default.
• W2003643802 hasConcept C86803240 @default.
• W2003643802 hasConceptScore W2003643802C104317684 @default.
• W2003643802 hasConceptScore W2003643802C107824862 @default.
• W2003643802 hasConceptScore W2003643802C143065580 @default.
• W2003643802 hasConceptScore W2003643802C153911025 @default.
• W2003643802 hasConceptScore W2003643802C178790620 @default.
• W2003643802 hasConceptScore W2003643802C181199279 @default.
• W2003643802 hasConceptScore W2003643802C185592680 @default.
• W2003643802 hasConceptScore W2003643802C2776449523 @default.
• W2003643802 hasConceptScore W2003643802C2777563447 @default.
• W2003643802 hasConceptScore W2003643802C41258723 @default.
• W2003643802 hasConceptScore W2003643802C55493867 @default.
• W2003643802 hasConceptScore W2003643802C67705224 @default.
• W2003643802 hasConceptScore W2003643802C82381507 @default.
• W2003643802 hasConceptScore W2003643802C86803240 @default.
• W2003643802 hasIssue "2" @default.
• W2003643802 hasLocation W20036438021 @default.
• W2003643802 hasLocation W20036438022 @default.
• W2003643802 hasLocation W20036438023 @default.
• W2003643802 hasOpenAccess W2003643802 @default.
• W2003643802 hasPrimaryLocation W20036438021 @default.
• W2003643802 hasRelatedWork W1484706750 @default.

• next