Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003646594> ?p ?o ?g. }
- W2003646594 endingPage "438" @default.
- W2003646594 startingPage "430" @default.
- W2003646594 abstract "Although cisplatin has been extensively used as a cancer chemotherapeutic agent for the treatment of various human cancers, it causes significant side effects such as nephrotoxicity and hepatotoxicity due to lethal bystander damage to normal cells. Thus, in the current study, we investigated the Oriental herbal medicine Bojungbangdocktang (BJBDT), as we reported previously its anti-angiogenic activity at nontoxic concentrations that could prevent cisplatin-induced toxicity and apoptosis in human normal breast epithelial cell MCF-10A, but not in MCF-7 and MDA MB-231 breast cancer cells. BJBDT protected cisplatin-induced cytotoxicity in MCF-10A cells and potentiated cytotoxicity and MMP loss in MCF-7 cells. Also, 4′,6-diamidino-2-phenylindole (DAPI) staining and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay revealed that BJBDT reduced cisplatin-induced apoptotic bodies in MCF-10A cells compared with cisplatin-treated control. Consistently, BJBDT attenuated the apoptotic portion sub-G1 DNA contents as well as blocked the activation of caspase-3 and -9 and poly(ADP-ribose)polymerase (PARP) cleavage in cisplatin-treated MCF-10A cells. Taken together, our findings suggest that BJBDT can protect cisplatin-induced cytotoxicity and apoptosis in normal MCF-10A breast cells as a cancer chemopreventive agent." @default.
- W2003646594 created "2016-06-24" @default.
- W2003646594 creator A5004812097 @default.
- W2003646594 creator A5026533271 @default.
- W2003646594 creator A5030816066 @default.
- W2003646594 creator A5037236595 @default.
- W2003646594 creator A5037898363 @default.
- W2003646594 creator A5046749364 @default.
- W2003646594 creator A5056824142 @default.
- W2003646594 creator A5069167592 @default.
- W2003646594 creator A5073484484 @default.
- W2003646594 creator A5083570047 @default.
- W2003646594 creator A5085421753 @default.
- W2003646594 creator A5091510154 @default.
- W2003646594 date "2009-11-01" @default.
- W2003646594 modified "2023-10-15" @default.
- W2003646594 title "Protective effect of Bojungbangdocktang on cisplatin-induced cytotoxicity and apoptosis in MCF-10A breast endothelial cells" @default.
- W2003646594 cites W1590029880 @default.
- W2003646594 cites W1974705316 @default.
- W2003646594 cites W1981106016 @default.
- W2003646594 cites W1990733040 @default.
- W2003646594 cites W1997899716 @default.
- W2003646594 cites W1998816744 @default.
- W2003646594 cites W2008395262 @default.
- W2003646594 cites W2024405339 @default.
- W2003646594 cites W2036294279 @default.
- W2003646594 cites W2042581554 @default.
- W2003646594 cites W2058364439 @default.
- W2003646594 cites W2060705503 @default.
- W2003646594 cites W2062932184 @default.
- W2003646594 cites W2063337619 @default.
- W2003646594 cites W2098712005 @default.
- W2003646594 cites W2104112421 @default.
- W2003646594 cites W2116495887 @default.
- W2003646594 cites W2119683782 @default.
- W2003646594 cites W2122142382 @default.
- W2003646594 cites W2130866079 @default.
- W2003646594 cites W2136695249 @default.
- W2003646594 cites W2144106984 @default.
- W2003646594 cites W2151501496 @default.
- W2003646594 cites W2154346380 @default.
- W2003646594 cites W2156912422 @default.
- W2003646594 cites W2171132622 @default.
- W2003646594 cites W2255784931 @default.
- W2003646594 cites W2316107449 @default.
- W2003646594 doi "https://doi.org/10.1016/j.etap.2009.07.007" @default.
- W2003646594 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21784039" @default.
- W2003646594 hasPublicationYear "2009" @default.
- W2003646594 type Work @default.
- W2003646594 sameAs 2003646594 @default.
- W2003646594 citedByCount "13" @default.
- W2003646594 countsByYear W20036465942012 @default.
- W2003646594 countsByYear W20036465942013 @default.
- W2003646594 countsByYear W20036465942015 @default.
- W2003646594 countsByYear W20036465942016 @default.
- W2003646594 countsByYear W20036465942017 @default.
- W2003646594 countsByYear W20036465942018 @default.
- W2003646594 countsByYear W20036465942019 @default.
- W2003646594 crossrefType "journal-article" @default.
- W2003646594 hasAuthorship W2003646594A5004812097 @default.
- W2003646594 hasAuthorship W2003646594A5026533271 @default.
- W2003646594 hasAuthorship W2003646594A5030816066 @default.
- W2003646594 hasAuthorship W2003646594A5037236595 @default.
- W2003646594 hasAuthorship W2003646594A5037898363 @default.
- W2003646594 hasAuthorship W2003646594A5046749364 @default.
- W2003646594 hasAuthorship W2003646594A5056824142 @default.
- W2003646594 hasAuthorship W2003646594A5069167592 @default.
- W2003646594 hasAuthorship W2003646594A5073484484 @default.
- W2003646594 hasAuthorship W2003646594A5083570047 @default.
- W2003646594 hasAuthorship W2003646594A5085421753 @default.
- W2003646594 hasAuthorship W2003646594A5091510154 @default.
- W2003646594 hasConcept C109316439 @default.
- W2003646594 hasConcept C109541995 @default.
- W2003646594 hasConcept C121608353 @default.
- W2003646594 hasConcept C143425029 @default.
- W2003646594 hasConcept C153911025 @default.
- W2003646594 hasConcept C154113507 @default.
- W2003646594 hasConcept C182979987 @default.
- W2003646594 hasConcept C185592680 @default.
- W2003646594 hasConcept C190283241 @default.
- W2003646594 hasConcept C196795494 @default.
- W2003646594 hasConcept C202751555 @default.
- W2003646594 hasConcept C2776694085 @default.
- W2003646594 hasConcept C2777527632 @default.
- W2003646594 hasConcept C2778239845 @default.
- W2003646594 hasConcept C2994423619 @default.
- W2003646594 hasConcept C502942594 @default.
- W2003646594 hasConcept C54355233 @default.
- W2003646594 hasConcept C552990157 @default.
- W2003646594 hasConcept C55493867 @default.
- W2003646594 hasConcept C82381507 @default.
- W2003646594 hasConcept C86803240 @default.
- W2003646594 hasConcept C96232424 @default.
- W2003646594 hasConcept C98274493 @default.
- W2003646594 hasConceptScore W2003646594C109316439 @default.
- W2003646594 hasConceptScore W2003646594C109541995 @default.
- W2003646594 hasConceptScore W2003646594C121608353 @default.
- W2003646594 hasConceptScore W2003646594C143425029 @default.