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• W2003647627 abstract "Summary Human mitochondrial DNA (mtDNA) encodes 13 of the polypeptides associated with the process of oxidative phosphorylation (OXPHOS), the cells most important ATP generating pathway. Until recently, the effects of mtDNA rearrangements on male fertility have been largely ignored. However, it is becoming increasingly evident that both point mutations and large‐scale deletions may have an impact on sperm motility and morphology. We discuss the implications of these rearrangements in the context of the clinical setting. We further discuss the possible consequences resulting from the transmission of sperm mtDNA deletions to the offspring. The role of nucleo‐cytoplasmic interaction is investigated in the context of nuclear transcription and replication factors that regulate mtDNA transcription and replication." @default.
• W2003647627 created "2016-06-24" @default.
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• W2003647627 creator A5062672772 @default.
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• W2003647627 date "2005-03-21" @default.
• W2003647627 modified "2023-10-17" @default.
• W2003647627 title "The impact of mitochondrial genetics on male infertility" @default.
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• W2003647627 doi "https://doi.org/10.1111/j.1365-2605.2005.00515.x" @default.
• W2003647627 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15811066" @default.
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