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- W2003648327 abstract "A series of dipeptide derivatives of l-dopa were synthesized and investigated for their pharmacological activity using the unilaterally 6-hydroxydopamine (6-OHDA)-lesioned rat as an experimental model of Parkinson’s disease. Among them, (S)-isopropyl 2-(2-amino-2-methylpropanamido)-3-(3,4-dihydroxyphenyl)propanoate (4g) was found to be the most active compound, with 106% AUC activity and 149% peak activity of l-dopa after oral administration." @default.
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- W2003648327 date "2013-10-01" @default.
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- W2003648327 title "Design, synthesis and biological evaluation of peptide derivatives of l-dopa as anti-parkinsonian agents" @default.
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- W2003648327 doi "https://doi.org/10.1016/j.bmcl.2013.08.007" @default.
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