FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003648592> ?p ?o ?g. }

• W2003648592 endingPage "1328" @default.
• W2003648592 startingPage "1314" @default.
• W2003648592 abstract "Recent studies on mouse and human skeletal muscle (SM) demonstrated the important link between mitochondrial function and the cellular metabolic adaptation. To identify key compensatory molecular mechanisms in response to chronic mitochondrial distress, we analyzed mice with ectopic SM respiratory uncoupling in uncoupling protein 1 transgenic (UCP1-TG) mice as model of muscle-specific compromised mitochondrial function. Here we describe a detailed metabolic reprogramming profile associated with mitochondrial perturbations in SM, triggering an increased protein turnover and amino acid metabolism with induced biosynthetic serine/1-carbon/glycine pathway and the longevity-promoting polyamine spermidine as well as the trans-sulfuration pathway. This is related to an induction of NADPH-generating pathways and glutathione metabolism as an adaptive mitohormetic response and defense against increased oxidative stress. Strikingly, consistent muscle retrograde signaling profiles were observed in acute stress states such as muscle cell starvation and lipid overload, muscle regeneration, and heart muscle inflammation, but not in response to exercise. We provide conclusive evidence for a key compensatory stress-signaling network that preserves cellular function, oxidative stress tolerance, and survival during conditions of increased SM mitochondrial distress, a metabolic reprogramming profile so far only demonstrated for cancer cells and heart muscle.—Ost, M., Keipert, S., van Schothorst, E. M., Donner, V., van der Stelt, I., Kipp, A. P., Petzke, K.-J., Jove, M., Pamplona, R., Portero-Otin, M., Keijer, J., Klaus, S. Muscle mitohormesis promotes cellular survival via serine/glycine pathway flux. FASEB J. 29, 1314-1328 (2015). www.fasebj.org" @default.
• W2003648592 created "2016-06-24" @default.
• W2003648592 creator A5001547362 @default.
• W2003648592 creator A5009972485 @default.
• W2003648592 creator A5024388784 @default.
• W2003648592 creator A5033433056 @default.
• W2003648592 creator A5034847939 @default.
• W2003648592 creator A5039971652 @default.
• W2003648592 creator A5050412857 @default.
• W2003648592 creator A5056077897 @default.
• W2003648592 creator A5071449113 @default.
• W2003648592 creator A5072345129 @default.
• W2003648592 creator A5074232571 @default.
• W2003648592 creator A5082809068 @default.
• W2003648592 date "2014-12-09" @default.
• W2003648592 modified "2023-10-15" @default.
• W2003648592 title "Muscle mitohormesis promotes cellular survival via serine/glycine pathway flux" @default.
• W2003648592 cites W1750981760 @default.
• W2003648592 cites W1880398352 @default.
• W2003648592 cites W1898238965 @default.
• W2003648592 cites W1929123223 @default.
• W2003648592 cites W1964799901 @default.
• W2003648592 cites W1968852002 @default.
• W2003648592 cites W1973887944 @default.
• W2003648592 cites W1975770944 @default.
• W2003648592 cites W1979877873 @default.
• W2003648592 cites W1980050227 @default.
• W2003648592 cites W1980638751 @default.
• W2003648592 cites W1993497859 @default.
• W2003648592 cites W2002583208 @default.
• W2003648592 cites W2004129180 @default.
• W2003648592 cites W2006070103 @default.
• W2003648592 cites W2008372207 @default.
• W2003648592 cites W2010512235 @default.
• W2003648592 cites W2014721903 @default.
• W2003648592 cites W2016855149 @default.
• W2003648592 cites W2017035524 @default.
• W2003648592 cites W2022899908 @default.
• W2003648592 cites W2023402149 @default.
• W2003648592 cites W2024946243 @default.
• W2003648592 cites W2025139842 @default.
• W2003648592 cites W2025983003 @default.
• W2003648592 cites W2028897202 @default.
• W2003648592 cites W2034679839 @default.
• W2003648592 cites W2036203075 @default.
• W2003648592 cites W2036787961 @default.
• W2003648592 cites W2041161107 @default.
• W2003648592 cites W2041764822 @default.
• W2003648592 cites W2043175458 @default.
• W2003648592 cites W2049758936 @default.
• W2003648592 cites W2051028757 @default.
• W2003648592 cites W2058712327 @default.
• W2003648592 cites W2059083151 @default.
• W2003648592 cites W2065403921 @default.
• W2003648592 cites W2077637111 @default.
• W2003648592 cites W2086073886 @default.
• W2003648592 cites W2094879159 @default.
• W2003648592 cites W2096783679 @default.
• W2003648592 cites W2105981289 @default.
• W2003648592 cites W2106736210 @default.
• W2003648592 cites W2108195113 @default.
• W2003648592 cites W2108740070 @default.
• W2003648592 cites W2110065044 @default.
• W2003648592 cites W2112873594 @default.
• W2003648592 cites W2117396891 @default.
• W2003648592 cites W2121383038 @default.
• W2003648592 cites W2121966499 @default.
• W2003648592 cites W2122612452 @default.
• W2003648592 cites W2125445685 @default.
• W2003648592 cites W2130158054 @default.
• W2003648592 cites W2134294998 @default.
• W2003648592 cites W2135417344 @default.
• W2003648592 cites W2136563400 @default.
• W2003648592 cites W2138707492 @default.
• W2003648592 cites W2139673146 @default.
• W2003648592 cites W2141029854 @default.
• W2003648592 cites W2143041700 @default.
• W2003648592 cites W2143881644 @default.
• W2003648592 cites W2145280166 @default.
• W2003648592 cites W2145741408 @default.
• W2003648592 cites W2147128975 @default.
• W2003648592 cites W2147459821 @default.
• W2003648592 cites W2153259001 @default.
• W2003648592 cites W2157906022 @default.
• W2003648592 cites W2159416200 @default.
• W2003648592 cites W2164343224 @default.
• W2003648592 cites W2168420558 @default.
• W2003648592 cites W2169091672 @default.
• W2003648592 cites W2169970397 @default.
• W2003648592 cites W2172937800 @default.
• W2003648592 cites W4230911071 @default.
• W2003648592 cites W53971307 @default.
• W2003648592 doi "https://doi.org/10.1096/fj.14-261503" @default.
• W2003648592 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25491309" @default.
• W2003648592 hasPublicationYear "2014" @default.
• W2003648592 type Work @default.
• W2003648592 sameAs 2003648592 @default.
• W2003648592 citedByCount "54" @default.

• next