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• W2003650650 abstract "The article by Barzokis is a well-argued, insightful thesis that challenges us to consider novel views of the aging and diseased brain. The particular strength of this article is that it should succeed in bringing to the forefront of our thinking an appreciation for the high degree of metabolic activity and concomitant energy cost associated with maintaining a heavily myelinated brain and how aging or aging with disease may impact on or be impacted by this process. White matter has a number of essential metabolic processes that are ongoing throughout life yet the vascular supply is less extensive than the gray matter. This relationship between demand for nutrient support and limited access to nutrients requires development of storage devices (e.g. high ferritin content of oligodendrocytes for iron storage) and increases the likelihood of functional failure following any event associated with compromise in nutrient delivery. The types of neurological events in which white matter involvement is seen are detailed in the Bartzokis article. However, frequently the white matter involvement is considered secondary or of less neurological consequence than accompanying gray matter damage. Perhaps, in view of the strong supporting data discussed in the Bartozkis article, the white matter involvement will be given greater consideration. As argued, continual degradation of white matter and fragmentation of myelin could result in continued or exacerbation of an inflammatory reaction that could prove resistant to therapeutic interventions that do not specifically target this region. The relationships to memory consolidation and myelination are particularly noteworthy in considering myelin deficits and cognitive function in Alzheimer’s disease (AD). Although the article was necessarily focused on white matter and hence white matter oligodendrocytes, the potential contribution of gray matter oligodendrocytes to myelin, cholesterol and iron metabolism are also relevant to the concepts set forth. The argument that oligodendrocytes have a high energy requirement and associated high iron requirement can be supported further than the studies referenced in the Bartzokis" @default.
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• W2003650650 date "2004-01-01" @default.
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• W2003650650 title "Myelin breakdown in Alzheimer’s disease: a commentary" @default.
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• W2003650650 doi "https://doi.org/10.1016/j.neurobiolaging.2003.06.004" @default.
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