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• W2003662972 abstract "We discuss the clinical characteristics of tics and Tourette's syndrome (TS) and also possible treatment options. Based upon an overview of published pathophysiological and PET data, and the results of a recent PET study of changes in opioid receptor binding in TS, we hypothesize that the disease arises due to dysfunction within the cingulate and orbitofrontal cortex. The beneficial effects of dopamine receptor antagonists and dopamine-depleting agents in TS are suggested to be mediated via basal ganglia-thalamofrontal circuits, while opioid agents may act directly on the cingulate." @default.
• W2003662972 created "2016-06-24" @default.
• W2003662972 creator A5025406092 @default.
• W2003662972 creator A5033686177 @default.
• W2003662972 creator A5090636374 @default.
• W2003662972 date "1996-06-01" @default.
• W2003662972 modified "2023-10-18" @default.
• W2003662972 title "Tourette's syndrome: a disorder of cingulate and orbitofrontal function?" @default.
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• W2003662972 doi "https://doi.org/10.1093/qjmed/89.6.401" @default.
• W2003662972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8758042" @default.
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