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- W2003668487 abstract "The effect of a series of five recently synthesized cationic diamidines on cell proliferation and polyamine metabolism was studied on cultures of the model Trypanosomatid Crithidia fasciculata. Compounds displaying two arylic moieties (CGP039937A and CGP040215A) were ten fold more cytostatic than those displaying only one arylic residue (CGP033829A, CGP035753A and CGP036958A). The depletion of intracellular polyamine, putrescine and spermidine, pools and the effect of these compounds on S-adenosylmethionine decarboxylase and putrescine uptake suggest the requirement of two arylic groups in their chemical structure to obtain measurable effects on both polyamine metabolism and cell growth." @default.
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- W2003668487 date "1996-08-01" @default.
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- W2003668487 title "Effects of cationic diamidines on polyamine metabolism in the trypanosomatid Crithidia fasciculata" @default.
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- W2003668487 doi "https://doi.org/10.1016/0024-3205(96)00411-0" @default.
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