FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003669563> ?p ?o ?g. }

• W2003669563 endingPage "68" @default.
• W2003669563 startingPage "59" @default.
• W2003669563 abstract "Disintegrins and disintegrin-like proteins are molecules found in the venom of four snake families (Atractaspididae, Elapidae, Viperidae, and Colubridae). The disintegrins are nonenzymatic proteins that inhibit cell-cell interactions, cell-matrix interactions, and signal transduction, and may have potential in the treatment of strokes, heart attacks, cancers, and osteoporosis. Prior to 1983, the venom of Crotalus scutulatus scutulatus (Mohave Rattlesnake) was known to be only neurotoxic; however, now there is evidence that these snakes can contain venom with: (1) neurotoxins; (2) hemorrhagins; and (3) both neurotoxins and hemorrhagins. In this study, two disintegrins, mojastin 1 and mojastin 2, from the venom of a Mohave rattlesnake collected in central Arizona (Pinal County), were isolated and characterized. The disintegrins in these venoms were identified by mass-analyzed laser desorption ionization/time-of-flight/time-of-flight (MALDI/TOF/TOF) mass spectrometry as having masses of 7.436 and 7.636 kDa. Their amino acid sequences are similar to crotratroxin, a disintegrin isolated from the venom of the western diamondback rattlesnake (C. atrox). The amino acid sequence of mojastin 1 was identical to the amino acid sequence of a disintegrin isolated from the venom of the Timber rattlesnake (C. horridus). The disintegrins from the Mohave rattlesnake venom were able to inhibit ADP-induced platelet aggregation in whole human blood both having IC50s of 13.8 nM, but were not effective in inhibiting the binding of human urinary bladder carcinoma cells (T24) to fibronectin." @default.
• W2003669563 created "2016-06-24" @default.
• W2003669563 creator A5008101786 @default.
• W2003669563 creator A5010857736 @default.
• W2003669563 creator A5021210234 @default.
• W2003669563 creator A5063624947 @default.
• W2003669563 creator A5070957952 @default.
• W2003669563 creator A5086132081 @default.
• W2003669563 date "2006-04-01" @default.
• W2003669563 modified "2023-10-01" @default.
• W2003669563 title "Isolation and characterization of two disintegrins inhibiting ADP-induced human platelet aggregation from the venom of Crotalus scutulatus scutulatus (Mohave Rattlesnake)" @default.
• W2003669563 cites W1491813101 @default.
• W2003669563 cites W1532085934 @default.
• W2003669563 cites W1608689063 @default.
• W2003669563 cites W1627718954 @default.
• W2003669563 cites W1629115159 @default.
• W2003669563 cites W1976643373 @default.
• W2003669563 cites W1979247499 @default.
• W2003669563 cites W1981952335 @default.
• W2003669563 cites W1990043963 @default.
• W2003669563 cites W1991530649 @default.
• W2003669563 cites W2010334414 @default.
• W2003669563 cites W2014099441 @default.
• W2003669563 cites W2015839210 @default.
• W2003669563 cites W2019554080 @default.
• W2003669563 cites W2022811527 @default.
• W2003669563 cites W2024102985 @default.
• W2003669563 cites W2028590427 @default.
• W2003669563 cites W2033536477 @default.
• W2003669563 cites W2042697475 @default.
• W2003669563 cites W2044607111 @default.
• W2003669563 cites W2045766819 @default.
• W2003669563 cites W2055126125 @default.
• W2003669563 cites W2059003564 @default.
• W2003669563 cites W2059633289 @default.
• W2003669563 cites W2063865688 @default.
• W2003669563 cites W2067888478 @default.
• W2003669563 cites W2070553674 @default.
• W2003669563 cites W2076851686 @default.
• W2003669563 cites W2088056286 @default.
• W2003669563 cites W2138723251 @default.
• W2003669563 cites W2166407135 @default.
• W2003669563 cites W234460068 @default.
• W2003669563 cites W2418523472 @default.
• W2003669563 cites W4206356470 @default.
• W2003669563 cites W4229708739 @default.
• W2003669563 cites W4235245453 @default.
• W2003669563 cites W2033506801 @default.
• W2003669563 doi "https://doi.org/10.1016/j.taap.2005.07.004" @default.
• W2003669563 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16084550" @default.
• W2003669563 hasPublicationYear "2006" @default.
• W2003669563 type Work @default.
• W2003669563 sameAs 2003669563 @default.
• W2003669563 citedByCount "35" @default.
• W2003669563 countsByYear W20036695632013 @default.
• W2003669563 countsByYear W20036695632014 @default.
• W2003669563 countsByYear W20036695632015 @default.
• W2003669563 countsByYear W20036695632016 @default.
• W2003669563 countsByYear W20036695632017 @default.
• W2003669563 countsByYear W20036695632018 @default.
• W2003669563 countsByYear W20036695632019 @default.
• W2003669563 countsByYear W20036695632020 @default.
• W2003669563 countsByYear W20036695632021 @default.
• W2003669563 countsByYear W20036695632023 @default.
• W2003669563 crossrefType "journal-article" @default.
• W2003669563 hasAuthorship W2003669563A5008101786 @default.
• W2003669563 hasAuthorship W2003669563A5010857736 @default.
• W2003669563 hasAuthorship W2003669563A5021210234 @default.
• W2003669563 hasAuthorship W2003669563A5063624947 @default.
• W2003669563 hasAuthorship W2003669563A5070957952 @default.
• W2003669563 hasAuthorship W2003669563A5086132081 @default.
• W2003669563 hasConcept C109523444 @default.
• W2003669563 hasConcept C185592680 @default.
• W2003669563 hasConcept C2776725428 @default.
• W2003669563 hasConcept C2778259572 @default.
• W2003669563 hasConcept C2779231127 @default.
• W2003669563 hasConcept C2779448229 @default.
• W2003669563 hasConcept C2780331750 @default.
• W2003669563 hasConcept C55493867 @default.
• W2003669563 hasConcept C55728118 @default.
• W2003669563 hasConcept C86803240 @default.
• W2003669563 hasConcept C98274493 @default.
• W2003669563 hasConceptScore W2003669563C109523444 @default.
• W2003669563 hasConceptScore W2003669563C185592680 @default.
• W2003669563 hasConceptScore W2003669563C2776725428 @default.
• W2003669563 hasConceptScore W2003669563C2778259572 @default.
• W2003669563 hasConceptScore W2003669563C2779231127 @default.
• W2003669563 hasConceptScore W2003669563C2779448229 @default.
• W2003669563 hasConceptScore W2003669563C2780331750 @default.
• W2003669563 hasConceptScore W2003669563C55493867 @default.
• W2003669563 hasConceptScore W2003669563C55728118 @default.
• W2003669563 hasConceptScore W2003669563C86803240 @default.
• W2003669563 hasConceptScore W2003669563C98274493 @default.
• W2003669563 hasIssue "1" @default.
• W2003669563 hasLocation W20036695631 @default.
• W2003669563 hasLocation W20036695632 @default.
• W2003669563 hasOpenAccess W2003669563 @default.
• W2003669563 hasPrimaryLocation W20036695631 @default.

• next