FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003669591> ?p ?o ?g. }

• W2003669591 endingPage "515" @default.
• W2003669591 startingPage "505" @default.
• W2003669591 abstract "Studies suggest that like selective 5-hydroxytryptamine (5-HT; serotonin) reuptake inhibitors, antagonists at neurokinin-1 receptors (NK(1)Rs) may have antidepressant and anxiolytic properties. NK(1)Rs are present in 5-HT innervated forebrain regions which may provide a common point of interaction between these two transmitter systems. This study aimed to investigate for cellular co-localization between NK(1)Rs and 5-HT receptor subtypes in mood-related brain regions in the rat forebrain. With experiments using fluorescence immunocytochemistry, double-labelling methods demonstrated a high degree of co-localization between NK(1)Rs and 5-HT(1A) receptors in most regions examined. Co-localization was highest in the medial septum (88% NK(1)R expressing cells were 5-HT(1A) receptor-positive) and hippocampal regions (e.g. dentate gyrus, 65%), followed by the lateral/basolateral amygdala (35%) and medial prefrontal cortex (31%). In contrast, co-localization between NK(1)Rs and 5-HT(2A) receptors was infrequent (< 8%) in most areas examined except for the hippocampus (e.g. CA3, 43%). Overall co-localization between NK(1)Rs and 5-HT(1A) receptors was much greater than that between NK(1)Rs and 5-HT(2A) receptors. Thus, these experiments demonstrate a high degree of co-localization between NK(1)Rs and 5-HT(1A) receptors in cortical and limbic regions of the rat forebrain. These findings suggest a novel site of interaction between NK(1)R antagonists and the 5-HT system." @default.
• W2003669591 created "2016-06-24" @default.
• W2003669591 creator A5000399608 @default.
• W2003669591 creator A5016717006 @default.
• W2003669591 creator A5030939361 @default.
• W2003669591 creator A5045987718 @default.
• W2003669591 creator A5056805080 @default.
• W2003669591 date "2011-11-05" @default.
• W2003669591 modified "2023-10-18" @default.
• W2003669591 title "Evidence for the differential co-localization of neurokinin-1 receptors with 5-HT receptor subtypes in rat forebrain" @default.
• W2003669591 cites W1483125751 @default.
• W2003669591 cites W1540911990 @default.
• W2003669591 cites W1555828690 @default.
• W2003669591 cites W1969801239 @default.
• W2003669591 cites W1970954584 @default.
• W2003669591 cites W1973285360 @default.
• W2003669591 cites W1974630918 @default.
• W2003669591 cites W1976748905 @default.
• W2003669591 cites W1976837940 @default.
• W2003669591 cites W1977144406 @default.
• W2003669591 cites W1978713404 @default.
• W2003669591 cites W1980106250 @default.
• W2003669591 cites W1980143995 @default.
• W2003669591 cites W1980583629 @default.
• W2003669591 cites W1980604666 @default.
• W2003669591 cites W1981776174 @default.
• W2003669591 cites W1981875451 @default.
• W2003669591 cites W1983303052 @default.
• W2003669591 cites W1987107538 @default.
• W2003669591 cites W1987905339 @default.
• W2003669591 cites W1988188726 @default.
• W2003669591 cites W1991593059 @default.
• W2003669591 cites W1991974510 @default.
• W2003669591 cites W1995322608 @default.
• W2003669591 cites W1996345484 @default.
• W2003669591 cites W1998507169 @default.
• W2003669591 cites W1999407276 @default.
• W2003669591 cites W2000706273 @default.
• W2003669591 cites W2001938271 @default.
• W2003669591 cites W2004172377 @default.
• W2003669591 cites W2004313085 @default.
• W2003669591 cites W2005159512 @default.
• W2003669591 cites W2006431157 @default.
• W2003669591 cites W2008661553 @default.
• W2003669591 cites W2010733076 @default.
• W2003669591 cites W2012359231 @default.
• W2003669591 cites W2013064699 @default.
• W2003669591 cites W2014001501 @default.
• W2003669591 cites W2014260438 @default.
• W2003669591 cites W2014641504 @default.
• W2003669591 cites W2015720385 @default.
• W2003669591 cites W2016983964 @default.
• W2003669591 cites W2018203713 @default.
• W2003669591 cites W2023800668 @default.
• W2003669591 cites W2025930929 @default.
• W2003669591 cites W2027305485 @default.
• W2003669591 cites W2027826213 @default.
• W2003669591 cites W2028524283 @default.
• W2003669591 cites W2029667058 @default.
• W2003669591 cites W2031622726 @default.
• W2003669591 cites W2033260700 @default.
• W2003669591 cites W2034951640 @default.
• W2003669591 cites W2036676038 @default.
• W2003669591 cites W2036842321 @default.
• W2003669591 cites W2038989561 @default.
• W2003669591 cites W2039547266 @default.
• W2003669591 cites W2040993378 @default.
• W2003669591 cites W2045030807 @default.
• W2003669591 cites W2045877881 @default.
• W2003669591 cites W2049838152 @default.
• W2003669591 cites W2052256895 @default.
• W2003669591 cites W2052638384 @default.
• W2003669591 cites W2053081316 @default.
• W2003669591 cites W2055498833 @default.
• W2003669591 cites W2055505440 @default.
• W2003669591 cites W2056515808 @default.
• W2003669591 cites W2060339801 @default.
• W2003669591 cites W2060589548 @default.
• W2003669591 cites W2066524898 @default.
• W2003669591 cites W2069045175 @default.
• W2003669591 cites W2070290419 @default.
• W2003669591 cites W2070446221 @default.
• W2003669591 cites W2072268612 @default.
• W2003669591 cites W2073679038 @default.
• W2003669591 cites W2076875536 @default.
• W2003669591 cites W2081853889 @default.
• W2003669591 cites W2082013116 @default.
• W2003669591 cites W2082369948 @default.
• W2003669591 cites W2084988952 @default.
• W2003669591 cites W2087774138 @default.
• W2003669591 cites W2087834131 @default.
• W2003669591 cites W2088781238 @default.
• W2003669591 cites W2090278531 @default.
• W2003669591 cites W2090473343 @default.
• W2003669591 cites W2093225726 @default.
• W2003669591 cites W2094938515 @default.
• W2003669591 cites W2095213614 @default.
• W2003669591 cites W2105119208 @default.

• next