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- W2003670034 abstract "2-Benzazepines, which are potentially good candidates for new drug therapies to treat skin wounds, were readily prepared from substituted cinnamylamide via an intramolecular Friedel–Crafts reaction. With few steps and effective reactions, the procedure enables a rapid derivatization of 2-benzazepines. Moreover, optically active 4-substituted-2-benzazepines were prepared from chiral α-substituted cinnamylamides, which were readily prepared by asymmetric α-alkylation of chiral cinnamyl oxazolidinone amides. We have easily prepared a library of more than 20 derivatives and examined the biological activity of the compounds." @default.
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- W2003670034 date "2012-04-10" @default.
- W2003670034 modified "2023-09-27" @default.
- W2003670034 title "Concise Synthesis of 2-Benzazepine Derivatives and Their Biological Activity" @default.
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- W2003670034 doi "https://doi.org/10.1021/jo300380z" @default.
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