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• W2003670753 abstract "A non-invasive method is described for estimating dopamine beta-hydroxylase (DBH) activity in sympathetic neurons. Our assay is based on the measurement of the in vivo rate of tritiated water (THO) release from dopamine specifically labeled in the beta-position ([beta-3H]DA). In validation of this method, we have establsihed in human subjects that 1) THO release from [beta-3H]DA correlates with [beta-3H]norepinephrine metabolite excretion, and 2) partial inhibition of DBH with disulfiram (5.5 mg/kg for 4 days) causes parallel decreases in these two indices of dopamine beta-hydroxylation. Since there is a strong correlation (r = 0.89; P < 0.05) between the effect of disulfiram on THO release and the effect of the drug on [3H]-norepinephrine metabolite excretion, our data indicate that the rate at which THO is liberated from [beta-3H]DA into the total body water can be used as an in vivo index of DBH activity." @default.
• W2003670753 created "2016-06-24" @default.
• W2003670753 creator A5030535082 @default.
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• W2003670753 date "1980-10-01" @default.
• W2003670753 modified "2023-10-14" @default.
• W2003670753 title "Anin VivoTritium Release Assay of Human Dopamine βHydroxylase*" @default.
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• W2003670753 doi "https://doi.org/10.1210/jcem-51-4-810" @default.
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