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- W2003671655 abstract "To evaluate the distribution of ultrasound examination of the fetal nasal bone length (NBL) according to biparietal diameter (BPD) at 15–20 weeks' gestation and the association between nasal bone hypoplasia and trisomy 21 in the Korean population. This study was done in the Maternal Fetal Medicine Unit of Samsung Cheil Hospital from September 2003 to February 2004. The study population included 453 Korean women with singleton pregnancy aged between 19 and 45 years. Ultrasound measurements of NBL were performed in a strict sagittal plan of the fetal head and other fetal biometry profiles were carried out before amniocentesis for fetal karyotyping. The nasal bone length and fetal biometry profiles were measured successfully in all fetuses. Nasal bone length measurement increased as a function of BPD (P < 0.001) showing a linear relationship and median length of NBL was 4.4 mm (range 2.0–7.5). The increase of the NBL throughout 15–20 weeks' gestation was given by the equation NBL (mm) = 0.0952!?BPD (mm) + 0.902 (R2 = 0.13, P < 0.001). There was no case of trisomy 21 in our study. The fetal nasal bone length in the Korean population was significantly shorter than that reported of the Caucasians and the African-Americans. A more extensive study should be conducted to be able to use the NBL as an early ultrasonographic screening marker for trisomy 21 and make it applicable to the Korean population. Table Distribution of the nasal bone length measurement (mm) according to biparietal diameter (mm) BPD Cases 5th percentile Median 95th percentile 25.1–30.0 4 3.0 3.9 5.0 30.1–35.0 111 2.5 4.0 5.8 35.1–40.0 210 3.0 4.3 6.4 40.1–45.0 107 3.6 4.8 6.6 45.1–50.0 21 3.8 5.6 7.5 Total 453 4.4 (2.0–7.5)" @default.
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- W2003671655 date "2004-08-01" @default.
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- W2003671655 title "P10.26: The distribution of fetal nasal bone length according to the biparietal diameter in the Korean population" @default.
- W2003671655 doi "https://doi.org/10.1002/uog.1522" @default.
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