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• W2003697411 abstract "The present paper describes a novel series of HCV RNA polymerase inhibitors based on a pyrazolo[1,5-a]pyrimidine scaffold bearing hydrophobic groups and an acidic functionality. Several compounds were optimized to low nanomolar potencies in a biochemical RdRp assay. SAR trends clearly reveal a stringent preference for a cyclohexyl group as one of the hydrophobes, and improved activities for carboxylic acid derivatives." @default.
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• W2003697411 date "2009-11-01" @default.
• W2003697411 modified "2023-10-18" @default.
• W2003697411 title "Pyrazolo[1,5-a]pyrimidine-based inhibitors of HCV polymerase" @default.
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• W2003697411 doi "https://doi.org/10.1016/j.bmcl.2009.09.087" @default.
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