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- W200370443 abstract "The effect of ricin, the phytotoxin from castor beans, as well as two of its isolated tryptic peptides, was studied on hepatoma tissue cell suspension cultures (HTC). The toxin at a 0.3 μg/ml concentration, for 3.105 cells/ml, has a cytostatic effect. Protein synthesis measured by the incorporation of tritiated-leucine in the cell begins to be inhibited after 30 min of incubation with ricin, 45 min and 60 min with respectively the peptides II1c and II2a, although protein synthesis is completely blocked after 2 h for a toxin concentration of 0.3 μg/ml. DNA synthesis is inhibited from 1 h on. Finally the level of the DNA slows down from 3 h on, whereas the level of RNA abruptly falls between 4 and 5 h." @default.
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- W200370443 date "1980-01-01" @default.
- W200370443 modified "2023-09-27" @default.
- W200370443 title "INHIBITION OF HEPATOMA TISSUE CULTURE CELL GROWTH AND OF CELLULAR PROTEIN, DNA AND RNA SYNTHESIS BY RICIN AND TWO OF ITS TRYPTIC PEPTIDES" @default.
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- W200370443 doi "https://doi.org/10.1016/b978-0-08-024952-0.50056-9" @default.
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