FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003704622> ?p ?o ?g. }

• W2003704622 endingPage "408" @default.
• W2003704622 startingPage "399" @default.
• W2003704622 abstract "Cutaneous melanoma is a life-threatening skin cancer because of its poorly understood invasive nature and high metastatic potential. This study examines the importance of eukaryotic translation initiation factor 5A2 (EIF5A2) in melanoma pathogenesis.We examined EIF5A2 expression in 459 melanocytic lesions using tissue microarray. In addition, melanoma cell lines were subjected to invasion and cell proliferation assays, zymography, FACS and real-time PCR to investigate the role of EIF5A2 in cancer progression.Positive EIF5A2 staining increased from dysplastic naevi to primary melanomas (PMs; P=0.001), and further increased in metastatic melanomas (P=0.044). Eukaryotic translation initiation factor 5A2 expression was correlated with melanoma thickness (P<0.001) and was inversely correlated with the 5-year survival of PM patients especially those with tumour ≤2 mm thick. Strikingly, none of the latter died within 5 years in EIF5A2-negative staining group. Cox regression analysis revealed that EIF5A2 is an independent prognostic marker. Further, we found that EIF5A2 is a novel downstream target of phosphorylated Akt. Both melanoma cell invasion and MMP-2 activity increased and decreased with EIF5A2 overexpression and knockdown, respectively.We for the first time showed that EIF5A2, as a target of PI3K/Akt, promotes melanoma cell invasion and may serve as a promising prognostic marker and a potential therapeutic target for melanoma." @default.
• W2003704622 created "2016-06-24" @default.
• W2003704622 creator A5011834043 @default.
• W2003704622 creator A5043732398 @default.
• W2003704622 creator A5053607199 @default.
• W2003704622 creator A5053961103 @default.
• W2003704622 creator A5059600260 @default.
• W2003704622 creator A5073231763 @default.
• W2003704622 creator A5091659506 @default.
• W2003704622 date "2013-10-31" @default.
• W2003704622 modified "2023-10-11" @default.
• W2003704622 title "Role of EIF5A2, a downstream target of Akt, in promoting melanoma cell invasion" @default.
• W2003704622 cites W1505083232 @default.
• W2003704622 cites W1506072704 @default.
• W2003704622 cites W1973142429 @default.
• W2003704622 cites W1979390430 @default.
• W2003704622 cites W2004010079 @default.
• W2003704622 cites W2013256513 @default.
• W2003704622 cites W2013464322 @default.
• W2003704622 cites W2013844329 @default.
• W2003704622 cites W2016036506 @default.
• W2003704622 cites W2019834045 @default.
• W2003704622 cites W2033744588 @default.
• W2003704622 cites W2041323674 @default.
• W2003704622 cites W2051144872 @default.
• W2003704622 cites W2055164218 @default.
• W2003704622 cites W2081527131 @default.
• W2003704622 cites W2086641174 @default.
• W2003704622 cites W2092868756 @default.
• W2003704622 cites W2092901172 @default.
• W2003704622 cites W2099888765 @default.
• W2003704622 cites W2101160383 @default.
• W2003704622 cites W2102723674 @default.
• W2003704622 cites W2114248978 @default.
• W2003704622 cites W2116657176 @default.
• W2003704622 cites W2127120957 @default.
• W2003704622 cites W2128453465 @default.
• W2003704622 cites W2129318139 @default.
• W2003704622 cites W2154209447 @default.
• W2003704622 cites W2163132288 @default.
• W2003704622 cites W2165138612 @default.
• W2003704622 cites W2165948908 @default.
• W2003704622 cites W2239490943 @default.
• W2003704622 cites W4244068819 @default.
• W2003704622 doi "https://doi.org/10.1038/bjc.2013.688" @default.
• W2003704622 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3899752" @default.
• W2003704622 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24178756" @default.
• W2003704622 hasPublicationYear "2013" @default.
• W2003704622 type Work @default.
• W2003704622 sameAs 2003704622 @default.
• W2003704622 citedByCount "41" @default.
• W2003704622 countsByYear W20037046222014 @default.
• W2003704622 countsByYear W20037046222015 @default.
• W2003704622 countsByYear W20037046222016 @default.
• W2003704622 countsByYear W20037046222017 @default.
• W2003704622 countsByYear W20037046222018 @default.
• W2003704622 countsByYear W20037046222019 @default.
• W2003704622 countsByYear W20037046222020 @default.
• W2003704622 countsByYear W20037046222021 @default.
• W2003704622 countsByYear W20037046222022 @default.
• W2003704622 crossrefType "journal-article" @default.
• W2003704622 hasAuthorship W2003704622A5011834043 @default.
• W2003704622 hasAuthorship W2003704622A5043732398 @default.
• W2003704622 hasAuthorship W2003704622A5053607199 @default.
• W2003704622 hasAuthorship W2003704622A5053961103 @default.
• W2003704622 hasAuthorship W2003704622A5059600260 @default.
• W2003704622 hasAuthorship W2003704622A5073231763 @default.
• W2003704622 hasAuthorship W2003704622A5091659506 @default.
• W2003704622 hasBestOaLocation W20037046221 @default.
• W2003704622 hasConcept C104317684 @default.
• W2003704622 hasConcept C105580179 @default.
• W2003704622 hasConcept C121608353 @default.
• W2003704622 hasConcept C126322002 @default.
• W2003704622 hasConcept C142724271 @default.
• W2003704622 hasConcept C1491633281 @default.
• W2003704622 hasConcept C149364088 @default.
• W2003704622 hasConcept C193270364 @default.
• W2003704622 hasConcept C204232928 @default.
• W2003704622 hasConcept C2777658100 @default.
• W2003704622 hasConcept C4718897 @default.
• W2003704622 hasConcept C502942594 @default.
• W2003704622 hasConcept C54355233 @default.
• W2003704622 hasConcept C55493867 @default.
• W2003704622 hasConcept C62478195 @default.
• W2003704622 hasConcept C71924100 @default.
• W2003704622 hasConcept C75217442 @default.
• W2003704622 hasConcept C86554907 @default.
• W2003704622 hasConcept C86803240 @default.
• W2003704622 hasConcept C95444343 @default.
• W2003704622 hasConcept C97154109 @default.
• W2003704622 hasConceptScore W2003704622C104317684 @default.
• W2003704622 hasConceptScore W2003704622C105580179 @default.
• W2003704622 hasConceptScore W2003704622C121608353 @default.
• W2003704622 hasConceptScore W2003704622C126322002 @default.
• W2003704622 hasConceptScore W2003704622C142724271 @default.
• W2003704622 hasConceptScore W2003704622C1491633281 @default.
• W2003704622 hasConceptScore W2003704622C149364088 @default.
• W2003704622 hasConceptScore W2003704622C193270364 @default.

• next