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- W2003704808 abstract "It is established that sponges, the phylogenetically oldest still extant phylum of Metazoa, possess key molecules of the apoptotic pathways, that is members from the Bcl-2 family and a pro-apoptotic molecule with death domains. Here we report on transfection studies of human cells with a sponge gene, GCBHP2. Sponge tissue was exposed to heat shock and tributyltin, which caused an upregulation of gene expression of GCBHP2. The cDNA GCBHP2 was introduced into human HEK-293 cells and mouse NIH-3T3 cells; the stable transfection was confirmed by the identification of the transcripts, by Western blotting as well as by immunofluorescence using antibodies raised against the recombinant polypeptide. HEK-293 cells, transfected with GCBHP2, showed high resistance to serum starvation and tributyltin treatment, compared to mock-transfected cells. In contrast to mock-transfected cells, GCBHP2-transfected cells activated caspase-3 to a lower extent. Thus, sponges contain gene(s) involved in apoptotic pathway(s) displaying their function also in human cells." @default.
- W2003704808 created "2016-06-24" @default.
- W2003704808 creator A5034644142 @default.
- W2003704808 creator A5042982991 @default.
- W2003704808 creator A5066605288 @default.
- W2003704808 date "2001-08-28" @default.
- W2003704808 modified "2023-10-09" @default.
- W2003704808 title "Sponge Bcl-2 homologous protein (BHP2-GC) confers distinct stress resistance to human HEK-293 cells" @default.
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- W2003704808 doi "https://doi.org/10.1038/sj.cdd.4400906" @default.
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