FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003706911> ?p ?o ?g. }

• W2003706911 abstract "Focusing of urokinase-type plasminogen activator (uPA) to the cell surface via binding to its specific receptor (uPAR, CD87) is critical for tumor invasion and metastasis. Consequently, the inhibition of uPA-uPAR interaction on the cell surface might be a promising anti-invasion and anti-metastasis strategy. We examined the effects of cDNA transfection of the human uPA amino-terminal fragment (ATF) on invasion and metastasis of cancer cells. First, a highly metastatic human lung giant-cell carcinoma cell line (PG), used as the target cell for evaluation of this effect, was demonstrated to express both uPA and uPAR. Then, ATF, which contains an intact uPAR binding site but is catalytically inactive, was designed as an antagonist of uPA-uPAR interaction and was transfected into PG cells. [(3)H]-Thymidine incorporation and cell growth curves indicated that expressed ATF did not affect the proliferation of transfected cells. However, analysis by scanning electron microscopy revealed that ATF changed the host cells from the typical invasive phenotype to a noninvasive one. Correspondingly, the modified Boyden chamber test in vitro showed that ATF expression significantly decreased the invasive capacity of transfected cells. Furthermore, in the spontaneous metastasis model, it was confirmed in vivo that expressed ATF remarkably inhibited lung metastasis of implanted ATF-transfected PG cells. In summary, autocrine ATF could act as an antagonist of uPA-uPAR interaction, and ATF cDNA transfection could efficiently inhibit the invasion and metastasis of the cancer cells. Inhibition of uPA-uPAR interaction on the cell surface might be a promising anti-invasion and anti-metastasis strategy." @default.
• W2003706911 created "2016-06-24" @default.
• W2003706911 creator A5010349565 @default.
• W2003706911 creator A5032423138 @default.
• W2003706911 creator A5036670052 @default.
• W2003706911 creator A5044874260 @default.
• W2003706911 creator A5077970099 @default.
• W2003706911 creator A5081534229 @default.
• W2003706911 date "2001-05-01" @default.
• W2003706911 modified "2023-09-26" @default.
• W2003706911 title "cDNA Transfection of Amino-Terminal Fragment of Urokinase Efficiently Inhibits Cancer Cell Invasion and Metastasis" @default.
• W2003706911 cites W130026199 @default.
• W2003706911 cites W1495239533 @default.
• W2003706911 cites W1521598031 @default.
• W2003706911 cites W1670027677 @default.
• W2003706911 cites W1853643611 @default.
• W2003706911 cites W1949259756 @default.
• W2003706911 cites W1977826373 @default.
• W2003706911 cites W1987278948 @default.
• W2003706911 cites W1990221290 @default.
• W2003706911 cites W1991160443 @default.
• W2003706911 cites W1992370535 @default.
• W2003706911 cites W1997375815 @default.
• W2003706911 cites W2003342945 @default.
• W2003706911 cites W2003843932 @default.
• W2003706911 cites W2016918804 @default.
• W2003706911 cites W2026223687 @default.
• W2003706911 cites W2054049732 @default.
• W2003706911 cites W2058390184 @default.
• W2003706911 cites W2064387750 @default.
• W2003706911 cites W2088738897 @default.
• W2003706911 cites W2106859452 @default.
• W2003706911 cites W247657422 @default.
• W2003706911 doi "https://doi.org/10.1089/104454901750232490" @default.
• W2003706911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11410166" @default.
• W2003706911 hasPublicationYear "2001" @default.
• W2003706911 type Work @default.
• W2003706911 sameAs 2003706911 @default.
• W2003706911 citedByCount "17" @default.
• W2003706911 countsByYear W20037069112012 @default.
• W2003706911 countsByYear W20037069112013 @default.
• W2003706911 countsByYear W20037069112015 @default.
• W2003706911 countsByYear W20037069112022 @default.
• W2003706911 crossrefType "journal-article" @default.
• W2003706911 hasAuthorship W2003706911A5010349565 @default.
• W2003706911 hasAuthorship W2003706911A5032423138 @default.
• W2003706911 hasAuthorship W2003706911A5036670052 @default.
• W2003706911 hasAuthorship W2003706911A5044874260 @default.
• W2003706911 hasAuthorship W2003706911A5077970099 @default.
• W2003706911 hasAuthorship W2003706911A5081534229 @default.
• W2003706911 hasConcept C121608353 @default.
• W2003706911 hasConcept C134018914 @default.
• W2003706911 hasConcept C1491633281 @default.
• W2003706911 hasConcept C153911025 @default.
• W2003706911 hasConcept C2779013556 @default.
• W2003706911 hasConcept C2779679481 @default.
• W2003706911 hasConcept C502942594 @default.
• W2003706911 hasConcept C54009773 @default.
• W2003706911 hasConcept C54355233 @default.
• W2003706911 hasConcept C55493867 @default.
• W2003706911 hasConcept C56219504 @default.
• W2003706911 hasConcept C62112901 @default.
• W2003706911 hasConcept C81885089 @default.
• W2003706911 hasConcept C86803240 @default.
• W2003706911 hasConcept C95444343 @default.
• W2003706911 hasConcept C96232424 @default.
• W2003706911 hasConceptScore W2003706911C121608353 @default.
• W2003706911 hasConceptScore W2003706911C134018914 @default.
• W2003706911 hasConceptScore W2003706911C1491633281 @default.
• W2003706911 hasConceptScore W2003706911C153911025 @default.
• W2003706911 hasConceptScore W2003706911C2779013556 @default.
• W2003706911 hasConceptScore W2003706911C2779679481 @default.
• W2003706911 hasConceptScore W2003706911C502942594 @default.
• W2003706911 hasConceptScore W2003706911C54009773 @default.
• W2003706911 hasConceptScore W2003706911C54355233 @default.
• W2003706911 hasConceptScore W2003706911C55493867 @default.
• W2003706911 hasConceptScore W2003706911C56219504 @default.
• W2003706911 hasConceptScore W2003706911C62112901 @default.
• W2003706911 hasConceptScore W2003706911C81885089 @default.
• W2003706911 hasConceptScore W2003706911C86803240 @default.
• W2003706911 hasConceptScore W2003706911C95444343 @default.
• W2003706911 hasConceptScore W2003706911C96232424 @default.
• W2003706911 hasLocation W20037069111 @default.
• W2003706911 hasLocation W20037069112 @default.
• W2003706911 hasOpenAccess W2003706911 @default.
• W2003706911 hasPrimaryLocation W20037069111 @default.
• W2003706911 hasRelatedWork W1275325292 @default.
• W2003706911 hasRelatedWork W1536849363 @default.
• W2003706911 hasRelatedWork W1542148298 @default.
• W2003706911 hasRelatedWork W1555312557 @default.
• W2003706911 hasRelatedWork W1574621194 @default.
• W2003706911 hasRelatedWork W1598733586 @default.
• W2003706911 hasRelatedWork W1970211701 @default.
• W2003706911 hasRelatedWork W1983589381 @default.
• W2003706911 hasRelatedWork W1992602800 @default.
• W2003706911 hasRelatedWork W2003593894 @default.
• W2003706911 hasRelatedWork W2008795652 @default.
• W2003706911 hasRelatedWork W2012923094 @default.
• W2003706911 hasRelatedWork W2016980425 @default.
• W2003706911 hasRelatedWork W2017615659 @default.

• next