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- W2003706919 abstract "The CACNG1 gene on chromosome 17q24 encodes an integral membrane protein that was originally isolated as the regulatory γ subunit of voltage-dependent Ca2+ channels from skeletal muscle. The existence of an extended family of γ subunits was subsequently demonstrated upon identification of CACNG2 (22q13), CACNG3 (16p12–p13), and CACNG4 and CACNG5 (17q24). In this study, we describe a cluster of three novel γ subunit genes, CACNG6, CACNG7, and CACNG8, located in a tandem array on 19q13.4. Phylogenetic analysis indicates that this array is paralogous to the cluster containing CACNG1, CACNG5, and CACNG4, respectively, on chromosome 17q24. We developed sensitive RT-PCR assays and examined the expression profile of each member of the γ subunit gene family, CACNG1–CACNG8. Analysis of 24 human tissues plus 3 dissected brain regions revealed that CACNG1 through CACNG8 are all coexpressed in fetal and adult brain and differentially transcribed among a wide variety of other tissues. The expression of distinct complements of γ subunit isoforms in different cell types may be an important mechanism for regulating Ca2+ channel function." @default.
- W2003706919 created "2016-06-24" @default.
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- W2003706919 date "2001-02-01" @default.
- W2003706919 modified "2023-10-12" @default.
- W2003706919 title "A Cluster of Three Novel Ca2+ Channel γ Subunit Genes on Chromosome 19q13.4: Evolution and Expression Profile of the γ Subunit Gene Family" @default.
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- W2003706919 doi "https://doi.org/10.1006/geno.2000.6440" @default.
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