FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003708006> ?p ?o ?g. }

• W2003708006 endingPage "23859" @default.
• W2003708006 startingPage "23852" @default.
• W2003708006 abstract "The preproteins targeted to the mitochondria are transported through the translocase of the outer membrane complex. Tom70/Tom71 is a major surface receptor of the translocase of the outer membrane complex for mitochondrial preproteins. The preproteins are escorted to Tom70/Tom71 by molecular chaperones Hsp70 and Hsp90. Here we present the high resolution crystal structures of Tom71 and the protein complexes between Tom71 and the Hsp70/Hsp90 C terminus. The crystal structures indicate that Tom70/Tom71 may exhibit two distinct states. In the closed state, the N-terminal domain of Tom70/Tom71 partially blocks the preprotein-binding pocket. In the open state, the N-terminal domain moves away, and the preprotein-binding pocket is fully exposed. The complex formation between the C-terminal EEVD motif of Hsp70/Hsp90 and Tom71 could lock Tom71 in the open state where the preprotein-binding pocket of Tom71 is ready to receive preproteins. The interactions between Hsp70/Hsp90 and Tom71 N-terminal domain generate conformational changes that may increase the volume of the preprotein-binding pocket. The complex formation of Hsp70/Hsp90 and Tom71 also generates significant domain rearrangement within Tom71, which may position the preprotein-binding pocket closer to Hsp70/Hsp90 to facilitate the preprotein transfer from the molecular chaperone to Tom71. Therefore, molecular chaperone Hsp70/Hsp90 may function to prepare the mitochondrial outer membrane receptor Tom71 for preprotein loading." @default.
• W2003708006 created "2016-06-24" @default.
• W2003708006 creator A5001202774 @default.
• W2003708006 creator A5011438584 @default.
• W2003708006 creator A5044142940 @default.
• W2003708006 creator A5065742678 @default.
• W2003708006 date "2009-08-01" @default.
• W2003708006 modified "2023-10-18" @default.
• W2003708006 title "Molecular Chaperone Hsp70/Hsp90 Prepares the Mitochondrial Outer Membrane Translocon Receptor Tom71 for Preprotein Loading" @default.
• W2003708006 cites W1605149529 @default.
• W2003708006 cites W1955276614 @default.
• W2003708006 cites W1967092231 @default.
• W2003708006 cites W1969672293 @default.
• W2003708006 cites W1972767281 @default.
• W2003708006 cites W1980751552 @default.
• W2003708006 cites W1998397779 @default.
• W2003708006 cites W1999778386 @default.
• W2003708006 cites W2001641653 @default.
• W2003708006 cites W2015588708 @default.
• W2003708006 cites W2028271694 @default.
• W2003708006 cites W2036794157 @default.
• W2003708006 cites W2039486080 @default.
• W2003708006 cites W2057247659 @default.
• W2003708006 cites W2067026289 @default.
• W2003708006 cites W2067511286 @default.
• W2003708006 cites W2072588550 @default.
• W2003708006 cites W2073523633 @default.
• W2003708006 cites W2077574127 @default.
• W2003708006 cites W2101011253 @default.
• W2003708006 cites W2107902575 @default.
• W2003708006 cites W2112200653 @default.
• W2003708006 cites W2126762966 @default.
• W2003708006 cites W2143401680 @default.
• W2003708006 cites W2144081223 @default.
• W2003708006 cites W2146149989 @default.
• W2003708006 cites W2147670071 @default.
• W2003708006 cites W2165563578 @default.
• W2003708006 cites W2462855682 @default.
• W2003708006 cites W4239023878 @default.
• W2003708006 cites W4242123597 @default.
• W2003708006 cites W4376848558 @default.
• W2003708006 doi "https://doi.org/10.1074/jbc.m109.023986" @default.
• W2003708006 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2749157" @default.
• W2003708006 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19581297" @default.
• W2003708006 hasPublicationYear "2009" @default.
• W2003708006 type Work @default.
• W2003708006 sameAs 2003708006 @default.
• W2003708006 citedByCount "68" @default.
• W2003708006 countsByYear W20037080062012 @default.
• W2003708006 countsByYear W20037080062013 @default.
• W2003708006 countsByYear W20037080062014 @default.
• W2003708006 countsByYear W20037080062015 @default.
• W2003708006 countsByYear W20037080062016 @default.
• W2003708006 countsByYear W20037080062017 @default.
• W2003708006 countsByYear W20037080062018 @default.
• W2003708006 countsByYear W20037080062019 @default.
• W2003708006 countsByYear W20037080062020 @default.
• W2003708006 countsByYear W20037080062021 @default.
• W2003708006 countsByYear W20037080062022 @default.
• W2003708006 countsByYear W20037080062023 @default.
• W2003708006 crossrefType "journal-article" @default.
• W2003708006 hasAuthorship W2003708006A5001202774 @default.
• W2003708006 hasAuthorship W2003708006A5011438584 @default.
• W2003708006 hasAuthorship W2003708006A5044142940 @default.
• W2003708006 hasAuthorship W2003708006A5065742678 @default.
• W2003708006 hasBestOaLocation W20037080061 @default.
• W2003708006 hasConcept C104317684 @default.
• W2003708006 hasConcept C113035283 @default.
• W2003708006 hasConcept C138626823 @default.
• W2003708006 hasConcept C142724271 @default.
• W2003708006 hasConcept C146587185 @default.
• W2003708006 hasConcept C159382241 @default.
• W2003708006 hasConcept C185592680 @default.
• W2003708006 hasConcept C186850619 @default.
• W2003708006 hasConcept C205260736 @default.
• W2003708006 hasConcept C2775932338 @default.
• W2003708006 hasConcept C2775962898 @default.
• W2003708006 hasConcept C28859421 @default.
• W2003708006 hasConcept C547475151 @default.
• W2003708006 hasConcept C55493867 @default.
• W2003708006 hasConcept C68991219 @default.
• W2003708006 hasConcept C71924100 @default.
• W2003708006 hasConcept C74897846 @default.
• W2003708006 hasConcept C75385678 @default.
• W2003708006 hasConcept C82266617 @default.
• W2003708006 hasConcept C86803240 @default.
• W2003708006 hasConcept C95444343 @default.
• W2003708006 hasConceptScore W2003708006C104317684 @default.
• W2003708006 hasConceptScore W2003708006C113035283 @default.
• W2003708006 hasConceptScore W2003708006C138626823 @default.
• W2003708006 hasConceptScore W2003708006C142724271 @default.
• W2003708006 hasConceptScore W2003708006C146587185 @default.
• W2003708006 hasConceptScore W2003708006C159382241 @default.
• W2003708006 hasConceptScore W2003708006C185592680 @default.
• W2003708006 hasConceptScore W2003708006C186850619 @default.
• W2003708006 hasConceptScore W2003708006C205260736 @default.
• W2003708006 hasConceptScore W2003708006C2775932338 @default.
• W2003708006 hasConceptScore W2003708006C2775962898 @default.

• next