FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003708432> ?p ?o ?g. }

• W2003708432 abstract "Accumulation and aggregation of amyloid-β (Aβ) peptides in the brain trigger the development of progressive neurodegeneration and dementia associated with Alzheimer's disease (AD). Perturbation in Aβ clearance, rather than Aβ production, is likely the cause of sporadic, late-onset AD, which accounts for the majority of AD cases. Since cellular uptake and subsequent degradation constitute a major Aβ clearance pathway, the receptor-mediated endocytosis of Aβ has been intensely investigated. Among Aβ receptors, the low-density lipoprotein receptor-related protein 1 (LRP1) is one of the most studied receptors. LRP1 is a large endocytic receptor for more than 40 ligands, including apolipoprotein E, α2-macroglobulin and Aβ. Emerging in vitro and in vivo evidence demonstrates that LRP1 is critically involved in brain Aβ clearance. LRP1 is highly expressed in a variety of cell types in the brain including neurons, vascular cells and glial cells, where LRP1 functions to maintain brain homeostasis and control Aβ metabolism. LRP1-mediated endocytosis regulates cellular Aβ uptake by binding to Aβ either directly or indirectly through its co-receptors or ligands. Furthermore, LRP1 regulates several signaling pathways, which also likely influences Aβ endocytic pathways. In this review, we discuss how LRP1 regulates the brain Aβ clearance and how this unique endocytic receptor participates in AD pathogenesis. Understanding of the mechanisms underlying LRP1-mediated Aβ clearance should enable the rational design of novel diagnostic and therapeutic strategies for AD." @default.
• W2003708432 created "2016-06-24" @default.
• W2003708432 creator A5025930339 @default.
• W2003708432 creator A5038413093 @default.
• W2003708432 date "2014-05-20" @default.
• W2003708432 modified "2023-10-04" @default.
• W2003708432 title "The low-density lipoprotein receptor-related protein 1 and amyloid-β clearance in Alzheimer’s disease" @default.
• W2003708432 cites W1508243540 @default.
• W2003708432 cites W1511615796 @default.
• W2003708432 cites W152075184 @default.
• W2003708432 cites W1527955859 @default.
• W2003708432 cites W1540257283 @default.
• W2003708432 cites W1543494855 @default.
• W2003708432 cites W1555380614 @default.
• W2003708432 cites W1581985161 @default.
• W2003708432 cites W1585678117 @default.
• W2003708432 cites W1602322875 @default.
• W2003708432 cites W1616122655 @default.
• W2003708432 cites W1923431801 @default.
• W2003708432 cites W1957213374 @default.
• W2003708432 cites W1964314802 @default.
• W2003708432 cites W1964357480 @default.
• W2003708432 cites W1966831629 @default.
• W2003708432 cites W1967546408 @default.
• W2003708432 cites W1967940232 @default.
• W2003708432 cites W1968721593 @default.
• W2003708432 cites W1969717742 @default.
• W2003708432 cites W1969828537 @default.
• W2003708432 cites W1970991314 @default.
• W2003708432 cites W1972161622 @default.
• W2003708432 cites W1972325849 @default.
• W2003708432 cites W1976824735 @default.
• W2003708432 cites W1977128117 @default.
• W2003708432 cites W1980226233 @default.
• W2003708432 cites W1981087370 @default.
• W2003708432 cites W1981117587 @default.
• W2003708432 cites W1984737558 @default.
• W2003708432 cites W1985720189 @default.
• W2003708432 cites W1989342312 @default.
• W2003708432 cites W1993160420 @default.
• W2003708432 cites W1997397907 @default.
• W2003708432 cites W1997703895 @default.
• W2003708432 cites W1997822484 @default.
• W2003708432 cites W1998118964 @default.
• W2003708432 cites W2000160553 @default.
• W2003708432 cites W2006035554 @default.
• W2003708432 cites W2006409771 @default.
• W2003708432 cites W2006534012 @default.
• W2003708432 cites W2008046104 @default.
• W2003708432 cites W2009401461 @default.
• W2003708432 cites W2010476270 @default.
• W2003708432 cites W2011846474 @default.
• W2003708432 cites W2011982570 @default.
• W2003708432 cites W2015704490 @default.
• W2003708432 cites W2017199725 @default.
• W2003708432 cites W2018455181 @default.
• W2003708432 cites W2018547586 @default.
• W2003708432 cites W2023357335 @default.
• W2003708432 cites W2026723397 @default.
• W2003708432 cites W2026935710 @default.
• W2003708432 cites W2028084402 @default.
• W2003708432 cites W2031762899 @default.
• W2003708432 cites W2032453195 @default.
• W2003708432 cites W2032607393 @default.
• W2003708432 cites W2033379465 @default.
• W2003708432 cites W2033630439 @default.
• W2003708432 cites W2034087941 @default.
• W2003708432 cites W2035026318 @default.
• W2003708432 cites W2036362108 @default.
• W2003708432 cites W2038943581 @default.
• W2003708432 cites W2040522662 @default.
• W2003708432 cites W2041371648 @default.
• W2003708432 cites W2047964142 @default.
• W2003708432 cites W2049806614 @default.
• W2003708432 cites W2051765035 @default.
• W2003708432 cites W2053351407 @default.
• W2003708432 cites W2053423892 @default.
• W2003708432 cites W2058071886 @default.
• W2003708432 cites W2058253080 @default.
• W2003708432 cites W2058880763 @default.
• W2003708432 cites W2060036340 @default.
• W2003708432 cites W2060117322 @default.
• W2003708432 cites W2061510546 @default.
• W2003708432 cites W2069174062 @default.
• W2003708432 cites W2069275980 @default.
• W2003708432 cites W2072082423 @default.
• W2003708432 cites W2072408699 @default.
• W2003708432 cites W2072682191 @default.
• W2003708432 cites W2073744343 @default.
• W2003708432 cites W2077576735 @default.
• W2003708432 cites W2081388499 @default.
• W2003708432 cites W2084969119 @default.
• W2003708432 cites W2085872177 @default.
• W2003708432 cites W2090097368 @default.
• W2003708432 cites W2091910339 @default.
• W2003708432 cites W2092014857 @default.
• W2003708432 cites W2093064359 @default.
• W2003708432 cites W2094117787 @default.
• W2003708432 cites W2095472825 @default.
• W2003708432 cites W2096410114 @default.

• next