FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003721774> ?p ?o ?g. }

• W2003721774 endingPage "8281" @default.
• W2003721774 startingPage "8276" @default.
• W2003721774 abstract "Abstract Adrenocortical carcinoma (ACC) is a rare disease with an overall poor but heterogeneous prognosis. This heterogeneity could reflect different mechanisms of tumor development. Gene expression profiling by transcriptome analysis led to ACC being divided into two groups of tumors with very different outcomes. Somatic inactivating mutations of the tumor suppressor gene TP53 and activating mutations of the proto-oncogene β-catenin (CTNNB1) are the most frequent mutations identified in ACC. This study investigates the correlation between p53 and β-catenin alterations and the molecular classification of ACC by transcriptome analysis of 51 adult sporadic ACCs. All TP53 and CTNNB1 mutations seemed to be mutually exclusive and were observed only in the poor-outcome ACC group. Most of the abnormal p53 and β-catenin immunostaining was also found in this group. Fifty-two percent of the poor-outcome ACC group had TP53 or CTNNB1 mutations and 60% had abnormal p53 or β-catenin immunostaining. Unsupervised clustering transcriptome analysis of this poor-outcome group revealed three different subgroups, two of them being associated with p53 or β-catenin alterations, respectively. Analysis of p53 and β-catenin target gene expressions in each cluster confirmed a profound and anticipated effect on tumor biology, with distinct profiles logically associated with the respective pathway alterations. The third group had no p53 or β-catenin alteration, suggesting other unidentified molecular defects. This study shows the important respective roles of p53 and β-catenin in ACC development, delineating subgroups of ACC with different tumorigenesis and outcomes. Cancer Res; 70(21); 8276–81. ©2010 AACR." @default.
• W2003721774 created "2016-06-24" @default.
• W2003721774 creator A5000374695 @default.
• W2003721774 creator A5008529320 @default.
• W2003721774 creator A5016397577 @default.
• W2003721774 creator A5021402469 @default.
• W2003721774 creator A5041215431 @default.
• W2003721774 creator A5042627121 @default.
• W2003721774 creator A5047064640 @default.
• W2003721774 creator A5050015004 @default.
• W2003721774 creator A5072348796 @default.
• W2003721774 creator A5074273393 @default.
• W2003721774 creator A5090172773 @default.
• W2003721774 date "2010-10-31" @default.
• W2003721774 modified "2023-10-18" @default.
• W2003721774 title "Transcriptome Analysis Reveals that p53 and β-Catenin Alterations Occur in a Group of Aggressive Adrenocortical Cancers" @default.
• W2003721774 cites W1984648882 @default.
• W2003721774 cites W2003456330 @default.
• W2003721774 cites W2010872613 @default.
• W2003721774 cites W2033246829 @default.
• W2003721774 cites W2066923659 @default.
• W2003721774 cites W2094027100 @default.
• W2003721774 cites W2098165008 @default.
• W2003721774 cites W2103134006 @default.
• W2003721774 cites W2105635119 @default.
• W2003721774 cites W2138550913 @default.
• W2003721774 cites W2138551378 @default.
• W2003721774 cites W2141197851 @default.
• W2003721774 cites W2145168501 @default.
• W2003721774 cites W2155188359 @default.
• W2003721774 cites W2157610967 @default.
• W2003721774 cites W2158106539 @default.
• W2003721774 cites W2170487994 @default.
• W2003721774 doi "https://doi.org/10.1158/0008-5472.can-10-2014" @default.
• W2003721774 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20959480" @default.
• W2003721774 hasPublicationYear "2010" @default.
• W2003721774 type Work @default.
• W2003721774 sameAs 2003721774 @default.
• W2003721774 citedByCount "129" @default.
• W2003721774 countsByYear W20037217742012 @default.
• W2003721774 countsByYear W20037217742013 @default.
• W2003721774 countsByYear W20037217742014 @default.
• W2003721774 countsByYear W20037217742015 @default.
• W2003721774 countsByYear W20037217742016 @default.
• W2003721774 countsByYear W20037217742017 @default.
• W2003721774 countsByYear W20037217742018 @default.
• W2003721774 countsByYear W20037217742019 @default.
• W2003721774 countsByYear W20037217742020 @default.
• W2003721774 countsByYear W20037217742021 @default.
• W2003721774 countsByYear W20037217742022 @default.
• W2003721774 countsByYear W20037217742023 @default.
• W2003721774 crossrefType "journal-article" @default.
• W2003721774 hasAuthorship W2003721774A5000374695 @default.
• W2003721774 hasAuthorship W2003721774A5008529320 @default.
• W2003721774 hasAuthorship W2003721774A5016397577 @default.
• W2003721774 hasAuthorship W2003721774A5021402469 @default.
• W2003721774 hasAuthorship W2003721774A5041215431 @default.
• W2003721774 hasAuthorship W2003721774A5042627121 @default.
• W2003721774 hasAuthorship W2003721774A5047064640 @default.
• W2003721774 hasAuthorship W2003721774A5050015004 @default.
• W2003721774 hasAuthorship W2003721774A5072348796 @default.
• W2003721774 hasAuthorship W2003721774A5074273393 @default.
• W2003721774 hasAuthorship W2003721774A5090172773 @default.
• W2003721774 hasBestOaLocation W20037217741 @default.
• W2003721774 hasConcept C104317684 @default.
• W2003721774 hasConcept C121608353 @default.
• W2003721774 hasConcept C126322002 @default.
• W2003721774 hasConcept C134018914 @default.
• W2003721774 hasConcept C137620995 @default.
• W2003721774 hasConcept C150194340 @default.
• W2003721774 hasConcept C162317418 @default.
• W2003721774 hasConcept C18431079 @default.
• W2003721774 hasConcept C203014093 @default.
• W2003721774 hasConcept C204232928 @default.
• W2003721774 hasConcept C2781018059 @default.
• W2003721774 hasConcept C2781399356 @default.
• W2003721774 hasConcept C29537977 @default.
• W2003721774 hasConcept C30145163 @default.
• W2003721774 hasConcept C4224716 @default.
• W2003721774 hasConcept C502942594 @default.
• W2003721774 hasConcept C54355233 @default.
• W2003721774 hasConcept C555283112 @default.
• W2003721774 hasConcept C71924100 @default.
• W2003721774 hasConcept C86803240 @default.
• W2003721774 hasConceptScore W2003721774C104317684 @default.
• W2003721774 hasConceptScore W2003721774C121608353 @default.
• W2003721774 hasConceptScore W2003721774C126322002 @default.
• W2003721774 hasConceptScore W2003721774C134018914 @default.
• W2003721774 hasConceptScore W2003721774C137620995 @default.
• W2003721774 hasConceptScore W2003721774C150194340 @default.
• W2003721774 hasConceptScore W2003721774C162317418 @default.
• W2003721774 hasConceptScore W2003721774C18431079 @default.
• W2003721774 hasConceptScore W2003721774C203014093 @default.
• W2003721774 hasConceptScore W2003721774C204232928 @default.
• W2003721774 hasConceptScore W2003721774C2781018059 @default.
• W2003721774 hasConceptScore W2003721774C2781399356 @default.
• W2003721774 hasConceptScore W2003721774C29537977 @default.
• W2003721774 hasConceptScore W2003721774C30145163 @default.

• next