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• W2003722130 abstract "•Reducing Chinmo in adult CySCs causes progressive feminization of the testis soma •As feminization is initiated, CySCs lose DsxM and gain female somatic markers •Feminized CySCs make progeny (follicle-like cells) that envelop arrested germ cells •Ectopic DsxM in the CySC lineage rescues the chinmo sex transformation phenotype Local signals maintain adult stem cells in many tissues. Whether the sexual identity of adult stem cells must also be maintained was not known. In the adult Drosophila testis niche, local Jak-STAT signaling promotes somatic cyst stem cell (CySC) renewal through several effectors, including the putative transcription factor Chronologically inappropriate morphogenesis (Chinmo). Here, we find that Chinmo also prevents feminization of CySCs. Chinmo promotes expression of the canonical male sex determination factor DoublesexM (DsxM) within CySCs and their progeny, and ectopic expression of DsxM in the CySC lineage partially rescues the chinmo sex transformation phenotype, placing Chinmo upstream of DsxM. The Dsx homolog DMRT1 prevents the male-to-female conversion of differentiated somatic cells in the adult mammalian testis, but its regulation is not well understood. Our work indicates that sex maintenance occurs in adult somatic stem cells and that this highly conserved process is governed by effectors of niche signals. PaperClip /cms/asset/39799f52-8ee5-49df-a4ff-6d716c5ae4bd/mmc3.mp3 Loading ... (mp3, 5.24 MB) Download audio Local signals maintain adult stem cells in many tissues. Whether the sexual identity of adult stem cells must also be maintained was not known. In the adult Drosophila testis niche, local Jak-STAT signaling promotes somatic cyst stem cell (CySC) renewal through several effectors, including the putative transcription factor Chronologically inappropriate morphogenesis (Chinmo). Here, we find that Chinmo also prevents feminization of CySCs. Chinmo promotes expression of the canonical male sex determination factor DoublesexM (DsxM) within CySCs and their progeny, and ectopic expression of DsxM in the CySC lineage partially rescues the chinmo sex transformation phenotype, placing Chinmo upstream of DsxM. The Dsx homolog DMRT1 prevents the male-to-female conversion of differentiated somatic cells in the adult mammalian testis, but its regulation is not well understood. Our work indicates that sex maintenance occurs in adult somatic stem cells and that this highly conserved process is governed by effectors of niche signals. chinmo Mutant Fly Testis Stem Cells Switching Sex Farewell to MalenessDavid ZarkowerDevelopmental CellNovember 24, 2014In BriefMaintaining cellular identity is crucial for homeostasis, and sexual fates of vertebrate testis and ovary cells require continual reinforcement. In this issue of Developmental Cell, Ma et al. (2014) provide insights into stem cell fate maintenance in Drosophila, finding that the JAK/STAT target chinmo prevents transformation of testis somatic stem cells into their ovarian counterparts. Full-Text PDF Open Archive" @default.
• W2003722130 created "2016-06-24" @default.
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• W2003722130 date "2014-11-01" @default.
• W2003722130 modified "2023-09-23" @default.
• W2003722130 title "The Jak-STAT Target Chinmo Prevents Sex Transformation of Adult Stem Cells in the Drosophila Testis Niche" @default.
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• W2003722130 doi "https://doi.org/10.1016/j.devcel.2014.10.004" @default.
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