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• W2003722255 startingPage "e112822" @default.
• W2003722255 abstract "The rise of resistances against antibiotics in bacteria is a major threat for public health and demands the development of novel antibacterial therapies. Infections with Pseudomonas aeruginosa are a severe problem for hospitalized patients and for patients suffering from cystic fibrosis. These bacteria can form biofilms and thereby increase their resistance towards antibiotics. The bacterial lectin LecB was shown to be necessary for biofilm formation and the inhibition with its carbohydrate ligands resulted in reduced amounts of biofilm. The natural ligands for LecB are glycosides of d-mannose and l-fucose, the latter displaying an unusual strong affinity. Interestingly, although mannosides are much weaker ligands for LecB, they do form an additional hydrogen bond with the protein in the crystal structure. To analyze the individual contributions of the methyl group in fucosides and the hydroxymethyl group in mannosides to the binding, we designed and synthesized derivatives of these saccharides. We report glycomimetic inhibitors that dissect the individual interactions of their saccharide precursors with LecB and give insight into the biophysics of binding by LecB. Furthermore, theoretical calculations supported by experimental thermodynamic data suggest a perturbed hydrogen bonding network for mannose derivatives as molecular basis for the selectivity of LecB for fucosides. Knowledge gained on the mode of interaction of LecB with its ligands at ambient conditions will be useful for future drug design." @default.
• W2003722255 created "2016-06-24" @default.
• W2003722255 creator A5018032298 @default.
• W2003722255 creator A5072497148 @default.
• W2003722255 creator A5076422921 @default.
• W2003722255 date "2014-11-21" @default.
• W2003722255 modified "2023-10-16" @default.
• W2003722255 title "A Biophysical Study with Carbohydrate Derivatives Explains the Molecular Basis of Monosaccharide Selectivity of the Pseudomonas aeruginosa Lectin LecB" @default.
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• W2003722255 doi "https://doi.org/10.1371/journal.pone.0112822" @default.
• W2003722255 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4240550" @default.
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• W2003722255 hasPublicationYear "2014" @default.
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