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• W2003729710 abstract "IL-10 modulation of human intestinal T lymphocyte functions was studied for the first time. Lymphocyte proliferation was determined by 3H-thymidine incorporation; cytokine production, by ELISA; expression of surface markers, by immunofluorescence and flow cytometric analysis; and cytotoxicity, by lysis of 51Cr-labelled target cells. IL-10 blocked phytohaemagglutinin (PHA)-induced activation and proliferation of CD8+ T cells from the epithelium and lamina propria. It was a greater inhibitor of IL-2, interferon-gamma, and tumour necrosis factor-alpha production than were IL-4 or transforming growth factor-beta. In contrast, IL-10 enhanced IL-2-stimulated proliferation of both CD4+ and CD8+ T cells by increasing cell division after activation. It also augmented IL-2- but not IL-15-induced cytotoxicity of intestinal lymphocytes against colon cancer by a mechanism independent of natural killer cells. In conclusion, IL-10 blocking of proinflammatory cytokine secretion probably reduces intestinal inflammation. IL-10 augmentation of IL-2-induced cytotoxicity may help to maintain host defence." @default.
• W2003729710 created "2016-06-24" @default.
• W2003729710 creator A5025377112 @default.
• W2003729710 date "2000-03-01" @default.
• W2003729710 modified "2023-09-27" @default.
• W2003729710 title "IL-10 enhances IL-2-induced proliferation and cytotoxicity by human intestinal lymphocytes" @default.
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• W2003729710 doi "https://doi.org/10.1046/j.1365-2249.2000.01147.x" @default.
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