Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003751122> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2003751122 endingPage "S27" @default.
- W2003751122 startingPage "S21" @default.
- W2003751122 abstract "Summary: Bradykinin is a potent vasodilating and natriuretic peptide, which is potentiated by angiotensin-converting enzyme (ACE) inhibitors. In our investigations we studied the effect of bradykinin on systemic and pulmonary circulation as well as on dorsal hand vein tone. The effects of bradykinin on systemic and pulmonary circulation were tested by injection of bradykinin into the right atrium. Parameters were determined for blood pressure, cardiac output, ECG and mean pressure in pulmonary artery. Heart rate, total peripheral resistance, pulmonary vascular resistance, and pulmonary arteriolar resistance were calculated by these measured parameters. The data raised in our investigations showed clearly that bradykinin reduced blood pressure by reducing total peripheral vascular resistance in a dose-dependent manner. In pulmonary circulation bradykinin develops a direct effect. All circulatory actions of bradykinin are not mediated by prostaglandins, since inhibition of prostaglandin synthesis by indomethacin (100–150 mg) was without any effect. ACE inhibition by ramipril (5 mg) or captopril (50 mg) potentiated all effects of bradykinin about 20- to 50-fold, whereas it decreased angiotensin I effects only about four- to fivefold. These results suggest, that endogenous kinins, if they will be similarly potentiated by ACE inhibition like the exogenous bradykinin in our experiments, might play an important role in the blood pressure lowering effect of ACE inhibitors. Dorsal hand vein tone was reduced by bradykinin too, indicating that kinins can lower cardiac preload by increasing venous blood pooling." @default.
- W2003751122 created "2016-06-24" @default.
- W2003751122 creator A5020554945 @default.
- W2003751122 creator A5031510031 @default.
- W2003751122 creator A5039742764 @default.
- W2003751122 creator A5044662521 @default.
- W2003751122 creator A5070512568 @default.
- W2003751122 creator A5090259771 @default.
- W2003751122 date "1992-01-01" @default.
- W2003751122 modified "2023-09-26" @default.
- W2003751122 title "Effect of Bradykinin on Arteries and Veins in Systemic and Pulmonary Circulation" @default.
- W2003751122 doi "https://doi.org/10.1097/00005344-199200209-00006" @default.
- W2003751122 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1282625" @default.
- W2003751122 hasPublicationYear "1992" @default.
- W2003751122 type Work @default.
- W2003751122 sameAs 2003751122 @default.
- W2003751122 citedByCount "24" @default.
- W2003751122 countsByYear W20037511222020 @default.
- W2003751122 countsByYear W20037511222022 @default.
- W2003751122 crossrefType "journal-article" @default.
- W2003751122 hasAuthorship W2003751122A5020554945 @default.
- W2003751122 hasAuthorship W2003751122A5031510031 @default.
- W2003751122 hasAuthorship W2003751122A5039742764 @default.
- W2003751122 hasAuthorship W2003751122A5044662521 @default.
- W2003751122 hasAuthorship W2003751122A5070512568 @default.
- W2003751122 hasAuthorship W2003751122A5090259771 @default.
- W2003751122 hasBestOaLocation W20037511221 @default.
- W2003751122 hasConcept C126322002 @default.
- W2003751122 hasConcept C134018914 @default.
- W2003751122 hasConcept C153939273 @default.
- W2003751122 hasConcept C164705383 @default.
- W2003751122 hasConcept C170493617 @default.
- W2003751122 hasConcept C27016395 @default.
- W2003751122 hasConcept C2779479957 @default.
- W2003751122 hasConcept C2779591629 @default.
- W2003751122 hasConcept C2780940725 @default.
- W2003751122 hasConcept C2908929049 @default.
- W2003751122 hasConcept C58245268 @default.
- W2003751122 hasConcept C71924100 @default.
- W2003751122 hasConcept C72859922 @default.
- W2003751122 hasConcept C84393581 @default.
- W2003751122 hasConceptScore W2003751122C126322002 @default.
- W2003751122 hasConceptScore W2003751122C134018914 @default.
- W2003751122 hasConceptScore W2003751122C153939273 @default.
- W2003751122 hasConceptScore W2003751122C164705383 @default.
- W2003751122 hasConceptScore W2003751122C170493617 @default.
- W2003751122 hasConceptScore W2003751122C27016395 @default.
- W2003751122 hasConceptScore W2003751122C2779479957 @default.
- W2003751122 hasConceptScore W2003751122C2779591629 @default.
- W2003751122 hasConceptScore W2003751122C2780940725 @default.
- W2003751122 hasConceptScore W2003751122C2908929049 @default.
- W2003751122 hasConceptScore W2003751122C58245268 @default.
- W2003751122 hasConceptScore W2003751122C71924100 @default.
- W2003751122 hasConceptScore W2003751122C72859922 @default.
- W2003751122 hasConceptScore W2003751122C84393581 @default.
- W2003751122 hasIssue "Supplement 9" @default.
- W2003751122 hasLocation W20037511221 @default.
- W2003751122 hasLocation W20037511222 @default.
- W2003751122 hasLocation W20037511223 @default.
- W2003751122 hasOpenAccess W2003751122 @default.
- W2003751122 hasPrimaryLocation W20037511221 @default.
- W2003751122 hasRelatedWork W1533842627 @default.
- W2003751122 hasRelatedWork W1984511346 @default.
- W2003751122 hasRelatedWork W2066868251 @default.
- W2003751122 hasRelatedWork W2075809833 @default.
- W2003751122 hasRelatedWork W2325452586 @default.
- W2003751122 hasRelatedWork W2401526116 @default.
- W2003751122 hasRelatedWork W2402165612 @default.
- W2003751122 hasRelatedWork W2435589063 @default.
- W2003751122 hasRelatedWork W30390160 @default.
- W2003751122 hasRelatedWork W2118665693 @default.
- W2003751122 hasVolume "20" @default.
- W2003751122 isParatext "false" @default.
- W2003751122 isRetracted "false" @default.
- W2003751122 magId "2003751122" @default.
- W2003751122 workType "article" @default.