Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003751718> ?p ?o ?g. }
- W2003751718 endingPage "12450" @default.
- W2003751718 startingPage "12445" @default.
- W2003751718 abstract "Condensins are ubiquitously expressed multiprotein complexes that are important for chromosome condensation and epigenetic regulation of gene transcription, but whose specific roles in vertebrates are poorly understood. We describe a mouse strain, nessy, isolated during an ethylnitrosourea screen for recessive immunological mutations. The nessy mouse has a defect in T lymphocyte development that decreases circulating T cell numbers, increases their expression of the activation/memory marker CD44, and dramatically decreases the numbers of CD4(+)CD8(+) thymocytes and their immediate DN4 precursors. A missense mutation in an unusual alternatively spliced first exon of the kleisin beta gene, a member of the condensin II complex, was shown to be responsible and act in a T cell-autonomous manner. Despite the ubiquitous expression and role of condensins, kleisin beta(nes/nes) mice were viable, fertile, and showed no defects even in the parallel pathway of B cell lymphocyte differentiation. These data define a unique lineage-specific requirement for kleisin beta in mammalian T cell differentiation." @default.
- W2003751718 created "2016-06-24" @default.
- W2003751718 creator A5002778129 @default.
- W2003751718 creator A5005819301 @default.
- W2003751718 creator A5010455484 @default.
- W2003751718 creator A5034805413 @default.
- W2003751718 creator A5035353912 @default.
- W2003751718 creator A5048318631 @default.
- W2003751718 creator A5053445551 @default.
- W2003751718 creator A5053483588 @default.
- W2003751718 creator A5054048579 @default.
- W2003751718 creator A5064103817 @default.
- W2003751718 creator A5069503356 @default.
- W2003751718 creator A5070851567 @default.
- W2003751718 creator A5074801897 @default.
- W2003751718 date "2007-07-24" @default.
- W2003751718 modified "2023-10-09" @default.
- W2003751718 title "A mutation in a chromosome condensin II subunit, kleisin β, specifically disrupts T cell development" @default.
- W2003751718 cites W1554149311 @default.
- W2003751718 cites W1893260165 @default.
- W2003751718 cites W1955496751 @default.
- W2003751718 cites W1984208534 @default.
- W2003751718 cites W1999041896 @default.
- W2003751718 cites W1999258315 @default.
- W2003751718 cites W2001201225 @default.
- W2003751718 cites W2005150833 @default.
- W2003751718 cites W2008992619 @default.
- W2003751718 cites W2017702380 @default.
- W2003751718 cites W2017756762 @default.
- W2003751718 cites W2021426943 @default.
- W2003751718 cites W2022073880 @default.
- W2003751718 cites W2025541016 @default.
- W2003751718 cites W2029364031 @default.
- W2003751718 cites W2031622194 @default.
- W2003751718 cites W2032334221 @default.
- W2003751718 cites W2032917789 @default.
- W2003751718 cites W2039704215 @default.
- W2003751718 cites W2054160631 @default.
- W2003751718 cites W2056374213 @default.
- W2003751718 cites W2056679356 @default.
- W2003751718 cites W2060372356 @default.
- W2003751718 cites W2064625809 @default.
- W2003751718 cites W2090385798 @default.
- W2003751718 cites W2107912726 @default.
- W2003751718 cites W2108441694 @default.
- W2003751718 cites W2114229638 @default.
- W2003751718 cites W2116824534 @default.
- W2003751718 cites W2128066698 @default.
- W2003751718 cites W2128106363 @default.
- W2003751718 cites W2136408524 @default.
- W2003751718 cites W2139715266 @default.
- W2003751718 cites W2142308337 @default.
- W2003751718 cites W2142614171 @default.
- W2003751718 cites W2145593944 @default.
- W2003751718 cites W2156475356 @default.
- W2003751718 cites W2162928535 @default.
- W2003751718 cites W2163867954 @default.
- W2003751718 cites W2168331489 @default.
- W2003751718 doi "https://doi.org/10.1073/pnas.0704870104" @default.
- W2003751718 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1941488" @default.
- W2003751718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17640884" @default.
- W2003751718 hasPublicationYear "2007" @default.
- W2003751718 type Work @default.
- W2003751718 sameAs 2003751718 @default.
- W2003751718 citedByCount "47" @default.
- W2003751718 countsByYear W20037517182012 @default.
- W2003751718 countsByYear W20037517182013 @default.
- W2003751718 countsByYear W20037517182014 @default.
- W2003751718 countsByYear W20037517182015 @default.
- W2003751718 countsByYear W20037517182016 @default.
- W2003751718 countsByYear W20037517182017 @default.
- W2003751718 countsByYear W20037517182018 @default.
- W2003751718 countsByYear W20037517182020 @default.
- W2003751718 countsByYear W20037517182021 @default.
- W2003751718 countsByYear W20037517182022 @default.
- W2003751718 countsByYear W20037517182023 @default.
- W2003751718 crossrefType "journal-article" @default.
- W2003751718 hasAuthorship W2003751718A5002778129 @default.
- W2003751718 hasAuthorship W2003751718A5005819301 @default.
- W2003751718 hasAuthorship W2003751718A5010455484 @default.
- W2003751718 hasAuthorship W2003751718A5034805413 @default.
- W2003751718 hasAuthorship W2003751718A5035353912 @default.
- W2003751718 hasAuthorship W2003751718A5048318631 @default.
- W2003751718 hasAuthorship W2003751718A5053445551 @default.
- W2003751718 hasAuthorship W2003751718A5053483588 @default.
- W2003751718 hasAuthorship W2003751718A5054048579 @default.
- W2003751718 hasAuthorship W2003751718A5064103817 @default.
- W2003751718 hasAuthorship W2003751718A5069503356 @default.
- W2003751718 hasAuthorship W2003751718A5070851567 @default.
- W2003751718 hasAuthorship W2003751718A5074801897 @default.
- W2003751718 hasBestOaLocation W20037517181 @default.
- W2003751718 hasConcept C104317684 @default.
- W2003751718 hasConcept C153911025 @default.
- W2003751718 hasConcept C155790170 @default.
- W2003751718 hasConcept C2778354886 @default.
- W2003751718 hasConcept C30481170 @default.
- W2003751718 hasConcept C501734568 @default.
- W2003751718 hasConcept C54355233 @default.