FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003753078> ?p ?o ?g. }

• W2003753078 abstract "The intestinal mucus layer plays a key role in the maintenance of host-microbiota homeostasis. To document the crosstalk between the host and microbiota, we used gnotobiotic models to study the influence of two major commensal bacteria, Bacteroides thetaiotaomicron and Faecalibacterium prausnitzii, on this intestinal mucus layer. B. thetaiotaomicron is known to use polysaccharides from mucus, but its effect on goblet cells has not been addressed so far. F. prausnitzii is of particular physiological importance because it can be considered as a sensor and a marker of human health. We determined whether B. thetaiotaomicron affected goblet cell differentiation, mucin synthesis and glycosylation in the colonic epithelium. We then investigated how F. prausnitzii influenced the colonic epithelial responses to B. thetaiotaomicron.B. thetaiotaomicron, an acetate producer, increased goblet cell differentiation, expression of mucus-related genes and the ratio of sialylated to sulfated mucins in mono-associated rats. B. thetaiotaomicron, therefore, stimulates the secretory lineage, favoring mucus production. When B. thetaiotaomicron was associated with F. prausnitzii, an acetate consumer and a butyrate producer, the effects on goblet cells and mucin glycosylation were diminished. F. prausnitzii, by attenuating the effects of B. thetaiotaomicron on mucus, may help the epithelium to maintain appropriate proportions of different cell types of the secretory lineage. Using a mucus-producing cell line, we showed that acetate up-regulated KLF4, a transcription factor involved in goblet cell differentiation.B. thetaiotaomicron and F. prausnitzii, which are metabolically complementary, modulate, in vivo, the intestinal mucus barrier by modifying goblet cells and mucin glycosylation. Our study reveals the importance of the balance between two main commensal bacteria in maintaining colonic epithelial homeostasis via their respective effects on mucus." @default.
• W2003753078 created "2016-06-24" @default.
• W2003753078 creator A5017080074 @default.
• W2003753078 creator A5027043028 @default.
• W2003753078 creator A5028223956 @default.
• W2003753078 creator A5031724130 @default.
• W2003753078 creator A5041459338 @default.
• W2003753078 creator A5041958551 @default.
• W2003753078 creator A5044134350 @default.
• W2003753078 creator A5060383645 @default.
• W2003753078 creator A5067363495 @default.
• W2003753078 creator A5069580401 @default.
• W2003753078 creator A5070804460 @default.
• W2003753078 creator A5076433007 @default.
• W2003753078 date "2013-05-21" @default.
• W2003753078 modified "2023-10-18" @default.
• W2003753078 title "Bacteroides thetaiotaomicron and Faecalibacterium prausnitziiinfluence the production of mucus glycans and the development of goblet cells in the colonic epithelium of a gnotobiotic model rodent" @default.
• W2003753078 cites W1491526770 @default.
• W2003753078 cites W1775749144 @default.
• W2003753078 cites W1900340618 @default.
• W2003753078 cites W1965554634 @default.
• W2003753078 cites W1967217097 @default.
• W2003753078 cites W1970807272 @default.
• W2003753078 cites W1976666264 @default.
• W2003753078 cites W1977781139 @default.
• W2003753078 cites W1980177626 @default.
• W2003753078 cites W2003099302 @default.
• W2003753078 cites W2003708547 @default.
• W2003753078 cites W2005741884 @default.
• W2003753078 cites W2009616940 @default.
• W2003753078 cites W2009706335 @default.
• W2003753078 cites W2020187741 @default.
• W2003753078 cites W2022338512 @default.
• W2003753078 cites W2025279306 @default.
• W2003753078 cites W2028520715 @default.
• W2003753078 cites W2028935316 @default.
• W2003753078 cites W2029943794 @default.
• W2003753078 cites W2030364983 @default.
• W2003753078 cites W2042045767 @default.
• W2003753078 cites W2044147680 @default.
• W2003753078 cites W2044482540 @default.
• W2003753078 cites W2044977356 @default.
• W2003753078 cites W2050016905 @default.
• W2003753078 cites W2052179475 @default.
• W2003753078 cites W2069697829 @default.
• W2003753078 cites W2072417345 @default.
• W2003753078 cites W2072945208 @default.
• W2003753078 cites W2076386438 @default.
• W2003753078 cites W2084512022 @default.
• W2003753078 cites W2084822759 @default.
• W2003753078 cites W2084831309 @default.
• W2003753078 cites W2086216523 @default.
• W2003753078 cites W2091564291 @default.
• W2003753078 cites W2101094027 @default.
• W2003753078 cites W2104901693 @default.
• W2003753078 cites W2106896953 @default.
• W2003753078 cites W2111612274 @default.
• W2003753078 cites W2112173425 @default.
• W2003753078 cites W2114089110 @default.
• W2003753078 cites W2114277486 @default.
• W2003753078 cites W2118593942 @default.
• W2003753078 cites W2120950548 @default.
• W2003753078 cites W2123806040 @default.
• W2003753078 cites W2123812491 @default.
• W2003753078 cites W2125826054 @default.
• W2003753078 cites W2127415562 @default.
• W2003753078 cites W2129723416 @default.
• W2003753078 cites W2134705504 @default.
• W2003753078 cites W2136294156 @default.
• W2003753078 cites W2136633470 @default.
• W2003753078 cites W2141125135 @default.
• W2003753078 cites W2144568881 @default.
• W2003753078 cites W2146467838 @default.
• W2003753078 cites W2148682389 @default.
• W2003753078 cites W2152805980 @default.
• W2003753078 cites W2156145269 @default.
• W2003753078 cites W2159184982 @default.
• W2003753078 cites W2159450781 @default.
• W2003753078 cites W2169330513 @default.
• W2003753078 cites W2300482125 @default.
• W2003753078 cites W4248422417 @default.
• W2003753078 cites W4294216491 @default.
• W2003753078 doi "https://doi.org/10.1186/1741-7007-11-61" @default.
• W2003753078 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3673873" @default.
• W2003753078 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23692866" @default.
• W2003753078 hasPublicationYear "2013" @default.
• W2003753078 type Work @default.
• W2003753078 sameAs 2003753078 @default.
• W2003753078 citedByCount "534" @default.
• W2003753078 countsByYear W20037530782013 @default.
• W2003753078 countsByYear W20037530782014 @default.
• W2003753078 countsByYear W20037530782015 @default.
• W2003753078 countsByYear W20037530782016 @default.
• W2003753078 countsByYear W20037530782017 @default.
• W2003753078 countsByYear W20037530782018 @default.
• W2003753078 countsByYear W20037530782019 @default.
• W2003753078 countsByYear W20037530782020 @default.
• W2003753078 countsByYear W20037530782021 @default.
• W2003753078 countsByYear W20037530782022 @default.
• W2003753078 countsByYear W20037530782023 @default.

• next