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• W2003754450 abstract "We report that a lactoperoxidase (LPO) metabolite derived from nitrite (NO2−) catalyses one-electron oxidation of biological electron donors and antioxidants such as NADH, NADPH, cysteine, glutathione, ascorbate, and Trolox C. The radical products of the reaction have been detected and identified using either direct EPR or EPR combined with spin trapping. While LPO/H2O2 alone generated only minute amounts of radicals from these compounds, the yield of radicals increased sharply when nitrite was also present. In aerated buffer (pH 7) the nitrite-dependent oxidation of NAD(P)H by LPO/H2O2 produced superoxide radical, O2•−, which was detected as a DMPO/O2H adduct. We propose that in the LPO/H2O2/NO2−/biological electron donor systems the nitrite functions as a catalyst because of its preferential oxidation by LPO to a strongly oxidizing metabolite, most likely a nitrogen dioxide radical NO2, which then reacts with the biological substrates more efficiently than does LPO/H2O2 alone. Because both nitrite and peroxidase enzymes are ubiquitous our observations point at a possible mechanism through which nitrite might exert its biological and cytotoxic action in vivo, and identify some of the physiological targets which might be affected by the peroxidase/H2O2/nitrite systems." @default.
• W2003754450 created "2016-06-24" @default.
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• W2003754450 date "1999-03-01" @default.
• W2003754450 modified "2023-10-13" @default.
• W2003754450 title "Oxidation of biological electron donors and antioxidants by a reactive lactoperoxidase metabolite from nitrite (NO2−): an EPR and spin trapping study" @default.
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• W2003754450 doi "https://doi.org/10.1016/s0891-5849(98)00244-5" @default.
• W2003754450 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10218656" @default.
• W2003754450 hasPublicationYear "1999" @default.
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