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- W2003754989 abstract "<h3>Background:</h3> d-β-Aspartic acid residues, which are biologically uncommon, have been reported to accumulate in various proteins of the living body with age. In the present study, d-β-aspartic acid-containing proteins were found to be localised in pingueculae, which represent one of the most prominent age-related ocular changes. <h3>Methods:</h3> Surgical specimens of conjunctivae with or without pingueculae were obtained from eight patients. Immunohistochemical localisation of d-β-aspartic acid-containing proteins was performed using a polyclonal antibody against d-β-aspartic acid-containing peptides. <h3>Results:</h3> Strong immunoreactivity to d-β-aspartic acid-containing peptides was detected in the subepithelial amorphous materials of all surgical specimens with pingueculae. In contrast, no immunoreactivity to d-β-aspartic acid-containing peptides was detected in the specimens without pingueculae. <h3>Conclusions:</h3> Pingueculae are thought to be aggregates of proteins that contain d-β-aspartic acid residues. It is known that the conversion of l- to d-aspartyl residues is accelerated by ultraviolet irradiation. In addition, d-β-aspartic acid-containing proteins, in general, tend to aggregate with each other and accumulate in the tissues. These facts indicate that ultraviolet irradiation-induced racemisation of aspartic acid is closely related to the development of pingueculae." @default.
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- W2003754989 date "2009-03-09" @default.
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- W2003754989 title "Immunohistochemical localisation of d- -aspartic acid in pingueculae" @default.
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- W2003754989 doi "https://doi.org/10.1136/bjo.2007.135889" @default.
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