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- W2003755059 abstract "A new bifunctional carborane ligand was prepared as a platform for the development of targeted molecular radioimaging and therapy agents. The carborane derivative was synthesized bearing a glucose substituent to increase the water solubility of the ligand and a benzoic acid group as a site for linking to amine containing targeting vectors. A convenient method to conjugate the ligand and the non-glycosylated analogue to amino groups was developed using simple active esters which were combined with a model amine generating two new N,N-diethyl(aminoethyl) benzamide derivatives. These were labelled with 125I in good yield and the log P values measured for [125I]-15 (log P = 0.82 ± 0.04) and [125I]-16 (log P = 1.53 ± 0.01). The benzamides were also evaluated for their capacity to bind to B16F10 melanoma cells where the hydrophilic compound showed low binding while [125I]-16 showed modest uptake (30.7 ± 2.2%) after 24 h." @default.
- W2003755059 created "2016-06-24" @default.
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- W2003755059 date "2009-05-01" @default.
- W2003755059 modified "2023-09-27" @default.
- W2003755059 title "Synthesis and screening of bifunctional radiolabelled carborane-carbohydrate derivatives" @default.
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- W2003755059 doi "https://doi.org/10.1016/j.jorganchem.2008.12.063" @default.
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