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- W2003755110 abstract "After a brief overview over the development of single molecule force spectroscopy and the basic concepts of bond dissociation under external force, we discuss the recently developed differential force assay, where a molecular bond serves as a microscopic force sensor. We introduce the basic concept of this novel biomolecular assay, discuss its requirements, capabilities and limitations, and present the latest advances in the design of the assay itself, as well as its appropriate hardware. The necessary data analysis procedures are introduced, and recent results showing the discrimination of single CC and GG mismatches within a 30 base pair DNA duplex are presented." @default.
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- W2003755110 date "2006-04-19" @default.
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- W2003755110 title "Differential analysis of biomolecular rupture forces" @default.
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- W2003755110 doi "https://doi.org/10.1088/0953-8984/18/18/s06" @default.
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