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• W2003755766 abstract "Inositol-requiring enzyme 1 (IRE1) is the most conserved transducer of the unfolded protein response (UPR), a homeostatic response that preserves proteostasis. Intriguingly, via its endoribonuclease activity, IRE1 produces either adaptive or death signals. This occurs through both unconventional splicing of XBP1 mRNA and regulated IRE1-dependent decay of mRNA (RIDD). Whereas XBP1 mRNA splicing is cytoprotective in response to endoplasmic reticulum (ER) stress, RIDD has revealed many unexpected features. For instance, RIDD cleaves RNA at an XBP1-like consensus site but with an activity divergent from XBP1 mRNA splicing and can either preserve ER homeostasis or induce cell death. Here we review recent findings on RIDD and propose a model of how IRE1 RNase activity might control cell fate decisions." @default.
• W2003755766 created "2016-06-24" @default.
• W2003755766 creator A5018735710 @default.
• W2003755766 creator A5048025852 @default.
• W2003755766 creator A5054994879 @default.
• W2003755766 creator A5061057486 @default.
• W2003755766 date "2014-05-01" @default.
• W2003755766 modified "2023-10-16" @default.
• W2003755766 title "Getting RIDD of RNA: IRE1 in cell fate regulation" @default.
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• W2003755766 doi "https://doi.org/10.1016/j.tibs.2014.02.008" @default.
• W2003755766 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24657016" @default.
• W2003755766 hasPublicationYear "2014" @default.
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