Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003757544> ?p ?o ?g. }
- W2003757544 endingPage "1156" @default.
- W2003757544 startingPage "1143" @default.
- W2003757544 abstract "The role of the growth hormone (GH)-insulin-like growth factor (IGF)-1 axis in the lifelong caloric restriction (CR)-associated remodeling of white adipose tissue (WAT), adipocyte size, and gene expression profiles was explored in this study. We analyzed the WAT morphology of 6–7-month-old wild-type Wistar rats fed ad libitum (WdAL) or subjected to CR (WdCR), and of heterozygous transgenic dwarf rats bearing an anti-sense GH transgene fed ad libitum (TgAL) or subjected to CR (TgCR). Although less effective in TgAL, the adipocyte size was significantly reduced in WdCR compared with WdAL. This CR effect was blunted in Tg rats. We also used high-density oligonucleotide microarrays to examine the gene expression profile of WAT of WdAL, WdCR, and TgAL rats. The gene expression profile of WdCR, but not TgAL, differed greatly from that of WdAL. The gene clusters with the largest changes induced by CR but not by Tg were genes involved in lipid biosynthesis and inflammation, particularly sterol regulatory element binding proteins (SREBPs)-regulated and macrophage-related genes, respectively. Real-time reverse-transcription polymerase chain reaction analysis confirmed that the expression of SREBP-1 and its downstream targets was upregulated, whereas the macrophage-related genes were downregulated in WdCR, but not in TgAL. In addition, CR affected the gene expression profile of Tg rats similarly to wild-type rats. Our findings suggest that CR-associated remodeling of WAT, which involves SREBP-1-mediated transcriptional activation and suppression of macrophage infiltration, is regulated in a GH–IGF-1-independent manner." @default.
- W2003757544 created "2016-06-24" @default.
- W2003757544 creator A5029461785 @default.
- W2003757544 creator A5039291203 @default.
- W2003757544 creator A5041815199 @default.
- W2003757544 creator A5043859294 @default.
- W2003757544 creator A5055431201 @default.
- W2003757544 creator A5056078040 @default.
- W2003757544 creator A5063082133 @default.
- W2003757544 creator A5071176004 @default.
- W2003757544 creator A5079280588 @default.
- W2003757544 creator A5084851803 @default.
- W2003757544 creator A5091718851 @default.
- W2003757544 date "2012-05-28" @default.
- W2003757544 modified "2023-10-17" @default.
- W2003757544 title "Caloric restriction-associated remodeling of rat white adipose tissue: effects on the growth hormone/insulin-like growth factor-1 axis, sterol regulatory element binding protein-1, and macrophage infiltration" @default.
- W2003757544 cites W1566575087 @default.
- W2003757544 cites W187764372 @default.
- W2003757544 cites W1935070596 @default.
- W2003757544 cites W1972561828 @default.
- W2003757544 cites W1973054372 @default.
- W2003757544 cites W1982647833 @default.
- W2003757544 cites W1983268104 @default.
- W2003757544 cites W1985425785 @default.
- W2003757544 cites W1985834536 @default.
- W2003757544 cites W1985880964 @default.
- W2003757544 cites W1994357518 @default.
- W2003757544 cites W2001854860 @default.
- W2003757544 cites W2007711341 @default.
- W2003757544 cites W2009172922 @default.
- W2003757544 cites W2028559279 @default.
- W2003757544 cites W2028883645 @default.
- W2003757544 cites W2034661709 @default.
- W2003757544 cites W2037254183 @default.
- W2003757544 cites W2051509673 @default.
- W2003757544 cites W2052609811 @default.
- W2003757544 cites W2054800029 @default.
- W2003757544 cites W2058512647 @default.
- W2003757544 cites W2061286916 @default.
- W2003757544 cites W2064230441 @default.
- W2003757544 cites W2066519654 @default.
- W2003757544 cites W2066762257 @default.
- W2003757544 cites W2069028126 @default.
- W2003757544 cites W2069988949 @default.
- W2003757544 cites W2088940658 @default.
- W2003757544 cites W2089022581 @default.
- W2003757544 cites W2099547258 @default.
- W2003757544 cites W2115709321 @default.
- W2003757544 cites W2116946811 @default.
- W2003757544 cites W2125076437 @default.
- W2003757544 cites W2125221913 @default.
- W2003757544 cites W2130617666 @default.
- W2003757544 cites W2131872615 @default.
- W2003757544 cites W2138486337 @default.
- W2003757544 cites W2145697808 @default.
- W2003757544 cites W2159979637 @default.
- W2003757544 cites W2160832259 @default.
- W2003757544 cites W2161239116 @default.
- W2003757544 cites W2162306102 @default.
- W2003757544 cites W2162338014 @default.
- W2003757544 cites W2163582576 @default.
- W2003757544 cites W2165202791 @default.
- W2003757544 cites W2170344274 @default.
- W2003757544 cites W4240174410 @default.
- W2003757544 doi "https://doi.org/10.1007/s11357-012-9439-1" @default.
- W2003757544 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3705091" @default.
- W2003757544 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22645024" @default.
- W2003757544 hasPublicationYear "2012" @default.
- W2003757544 type Work @default.
- W2003757544 sameAs 2003757544 @default.
- W2003757544 citedByCount "26" @default.
- W2003757544 countsByYear W20037575442014 @default.
- W2003757544 countsByYear W20037575442015 @default.
- W2003757544 countsByYear W20037575442016 @default.
- W2003757544 countsByYear W20037575442017 @default.
- W2003757544 countsByYear W20037575442018 @default.
- W2003757544 countsByYear W20037575442019 @default.
- W2003757544 countsByYear W20037575442020 @default.
- W2003757544 countsByYear W20037575442021 @default.
- W2003757544 countsByYear W20037575442023 @default.
- W2003757544 crossrefType "journal-article" @default.
- W2003757544 hasAuthorship W2003757544A5029461785 @default.
- W2003757544 hasAuthorship W2003757544A5039291203 @default.
- W2003757544 hasAuthorship W2003757544A5041815199 @default.
- W2003757544 hasAuthorship W2003757544A5043859294 @default.
- W2003757544 hasAuthorship W2003757544A5055431201 @default.
- W2003757544 hasAuthorship W2003757544A5056078040 @default.
- W2003757544 hasAuthorship W2003757544A5063082133 @default.
- W2003757544 hasAuthorship W2003757544A5071176004 @default.
- W2003757544 hasAuthorship W2003757544A5079280588 @default.
- W2003757544 hasAuthorship W2003757544A5084851803 @default.
- W2003757544 hasAuthorship W2003757544A5091718851 @default.
- W2003757544 hasBestOaLocation W20037575442 @default.
- W2003757544 hasConcept C102230213 @default.
- W2003757544 hasConcept C104317684 @default.
- W2003757544 hasConcept C126322002 @default.
- W2003757544 hasConcept C134018914 @default.
- W2003757544 hasConcept C150194340 @default.