Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003764496> ?p ?o ?g. }
- W2003764496 endingPage "9080" @default.
- W2003764496 startingPage "9069" @default.
- W2003764496 abstract "Decidual macrophages (DM) are the second most abundant population in the fetal-maternal interface. Their role has been so far identified as being local immuno-modulators favoring the maternal tolerance to the fetus. Herein we investigated tissue samples from 11 cases of spontaneous miscarriages and from 9 cases of elective terminations of pregnancy. Using immunohistochemistry and dual immunofluorescence we have demonstrated that in spontaneous miscarriages the DM are significantly increased. Additionally, we noted a significant up-regulation of macrophage FasL expression. Our results further support a dual role for DM during pregnancy and miscarriages. We hypothesize that the baseline DM population in normal pregnancy is in line with an M2 phenotype supporting the ongoing gestation. In contrast, during spontaneous miscarriages, the increased FasL-expressing population could be a part of an M1 phenotype participating in Fas/FasL-related apoptosis. Our results highlight a new aspect of macrophage biology in pregnancy physiology and pathophysiology. Further studies with larger samples are needed to verify the current results and evaluate their clinical impact." @default.
- W2003764496 created "2016-06-24" @default.
- W2003764496 creator A5013313461 @default.
- W2003764496 creator A5014424241 @default.
- W2003764496 creator A5014433662 @default.
- W2003764496 creator A5035590576 @default.
- W2003764496 creator A5044467977 @default.
- W2003764496 creator A5050124544 @default.
- W2003764496 creator A5051181833 @default.
- W2003764496 creator A5060169968 @default.
- W2003764496 creator A5077256353 @default.
- W2003764496 creator A5083439122 @default.
- W2003764496 creator A5083440074 @default.
- W2003764496 date "2012-07-20" @default.
- W2003764496 modified "2023-10-15" @default.
- W2003764496 title "Decidual Macrophages Are Significantly Increased in Spontaneous Miscarriages and Over-Express FasL: A Potential Role for Macrophages in Trophoblast Apoptosis" @default.
- W2003764496 cites W1498159349 @default.
- W2003764496 cites W1522750599 @default.
- W2003764496 cites W1585944187 @default.
- W2003764496 cites W1659380298 @default.
- W2003764496 cites W174419708 @default.
- W2003764496 cites W1971739874 @default.
- W2003764496 cites W1977776775 @default.
- W2003764496 cites W1983887692 @default.
- W2003764496 cites W1987823475 @default.
- W2003764496 cites W2004286915 @default.
- W2003764496 cites W2015260577 @default.
- W2003764496 cites W2017098602 @default.
- W2003764496 cites W2026044645 @default.
- W2003764496 cites W2036106861 @default.
- W2003764496 cites W2038689279 @default.
- W2003764496 cites W2070855360 @default.
- W2003764496 cites W2086089890 @default.
- W2003764496 cites W2101699830 @default.
- W2003764496 cites W2107504790 @default.
- W2003764496 cites W2111676688 @default.
- W2003764496 cites W2128138880 @default.
- W2003764496 cites W2129928771 @default.
- W2003764496 cites W2129937015 @default.
- W2003764496 cites W2130458764 @default.
- W2003764496 cites W2144273455 @default.
- W2003764496 cites W2150401131 @default.
- W2003764496 cites W2151588367 @default.
- W2003764496 cites W2157099277 @default.
- W2003764496 cites W2163175900 @default.
- W2003764496 cites W2167399827 @default.
- W2003764496 doi "https://doi.org/10.3390/ijms13079069" @default.
- W2003764496 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3430283" @default.
- W2003764496 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22942752" @default.
- W2003764496 hasPublicationYear "2012" @default.
- W2003764496 type Work @default.
- W2003764496 sameAs 2003764496 @default.
- W2003764496 citedByCount "58" @default.
- W2003764496 countsByYear W20037644962013 @default.
- W2003764496 countsByYear W20037644962014 @default.
- W2003764496 countsByYear W20037644962015 @default.
- W2003764496 countsByYear W20037644962016 @default.
- W2003764496 countsByYear W20037644962017 @default.
- W2003764496 countsByYear W20037644962018 @default.
- W2003764496 countsByYear W20037644962019 @default.
- W2003764496 countsByYear W20037644962020 @default.
- W2003764496 countsByYear W20037644962021 @default.
- W2003764496 countsByYear W20037644962022 @default.
- W2003764496 countsByYear W20037644962023 @default.
- W2003764496 crossrefType "journal-article" @default.
- W2003764496 hasAuthorship W2003764496A5013313461 @default.
- W2003764496 hasAuthorship W2003764496A5014424241 @default.
- W2003764496 hasAuthorship W2003764496A5014433662 @default.
- W2003764496 hasAuthorship W2003764496A5035590576 @default.
- W2003764496 hasAuthorship W2003764496A5044467977 @default.
- W2003764496 hasAuthorship W2003764496A5050124544 @default.
- W2003764496 hasAuthorship W2003764496A5051181833 @default.
- W2003764496 hasAuthorship W2003764496A5060169968 @default.
- W2003764496 hasAuthorship W2003764496A5077256353 @default.
- W2003764496 hasAuthorship W2003764496A5083439122 @default.
- W2003764496 hasAuthorship W2003764496A5083440074 @default.
- W2003764496 hasBestOaLocation W20037644961 @default.
- W2003764496 hasConcept C10162356 @default.
- W2003764496 hasConcept C104317684 @default.
- W2003764496 hasConcept C127716648 @default.
- W2003764496 hasConcept C134018914 @default.
- W2003764496 hasConcept C16685009 @default.
- W2003764496 hasConcept C172680121 @default.
- W2003764496 hasConcept C190283241 @default.
- W2003764496 hasConcept C202751555 @default.
- W2003764496 hasConcept C203014093 @default.
- W2003764496 hasConcept C204232928 @default.
- W2003764496 hasConcept C2776953305 @default.
- W2003764496 hasConcept C2777495146 @default.
- W2003764496 hasConcept C2779234561 @default.
- W2003764496 hasConcept C2779244956 @default.
- W2003764496 hasConcept C2908647359 @default.
- W2003764496 hasConcept C31573885 @default.
- W2003764496 hasConcept C54355233 @default.
- W2003764496 hasConcept C66008609 @default.
- W2003764496 hasConcept C71924100 @default.
- W2003764496 hasConcept C86803240 @default.
- W2003764496 hasConcept C99454951 @default.