Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003774034> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2003774034 endingPage "187" @default.
- W2003774034 startingPage "179" @default.
- W2003774034 abstract "X537A released histamine from isolated histamine-retaining mast cell granules incubated at 37 °C in Tris-sodium (150 m<i>M</i>) or Tris-potassium (150 m<i>M</i>), but not in Tris-glucose (300 m<i>M</i>). The release was depressed at 0 °C. In contrast, decylamine released all histamine bound to the granules irrespective of the presence of monovalent cations in the incubation medium or temperature. X537A did not release histamine from an artificial heparin-protamine complex when incubated in deionized water. The mechanism of histamine release by X537A can be explained by the ability of the ionophore to carry monovalent cations across cellular membranes, hereby making the ions available for exchange with histamine bound to the granular matrix. This mechanism can be distinguished from that of agents triggering an exchange between cations and bound histamine through a calcium- and energy-dependent exocytotic process on the one hand and through membrane lysis on the other. Based on the observation that the ionophore was able to carry histamine into the bulk of an organic phase, various possibilities exist to explain how histamine escapes from the cells following release from intracellular granular stores." @default.
- W2003774034 created "2016-06-24" @default.
- W2003774034 creator A5035634631 @default.
- W2003774034 creator A5053468956 @default.
- W2003774034 creator A5085704621 @default.
- W2003774034 date "1978-01-01" @default.
- W2003774034 modified "2023-09-26" @default.
- W2003774034 title "Mechanism of Histamine Release Induced by the Ionophore X537A from Isolated Rat Mast Cells" @default.
- W2003774034 doi "https://doi.org/10.1159/000232021" @default.
- W2003774034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/74363" @default.
- W2003774034 hasPublicationYear "1978" @default.
- W2003774034 type Work @default.
- W2003774034 sameAs 2003774034 @default.
- W2003774034 citedByCount "10" @default.
- W2003774034 crossrefType "journal-article" @default.
- W2003774034 hasAuthorship W2003774034A5035634631 @default.
- W2003774034 hasAuthorship W2003774034A5053468956 @default.
- W2003774034 hasAuthorship W2003774034A5085704621 @default.
- W2003774034 hasConcept C1122143 @default.
- W2003774034 hasConcept C12554922 @default.
- W2003774034 hasConcept C134018914 @default.
- W2003774034 hasConcept C178790620 @default.
- W2003774034 hasConcept C185592680 @default.
- W2003774034 hasConcept C203014093 @default.
- W2003774034 hasConcept C2779014961 @default.
- W2003774034 hasConcept C2779726688 @default.
- W2003774034 hasConcept C2781014771 @default.
- W2003774034 hasConcept C41625074 @default.
- W2003774034 hasConcept C519063684 @default.
- W2003774034 hasConcept C55493867 @default.
- W2003774034 hasConcept C57409179 @default.
- W2003774034 hasConcept C79879829 @default.
- W2003774034 hasConcept C86803240 @default.
- W2003774034 hasConceptScore W2003774034C1122143 @default.
- W2003774034 hasConceptScore W2003774034C12554922 @default.
- W2003774034 hasConceptScore W2003774034C134018914 @default.
- W2003774034 hasConceptScore W2003774034C178790620 @default.
- W2003774034 hasConceptScore W2003774034C185592680 @default.
- W2003774034 hasConceptScore W2003774034C203014093 @default.
- W2003774034 hasConceptScore W2003774034C2779014961 @default.
- W2003774034 hasConceptScore W2003774034C2779726688 @default.
- W2003774034 hasConceptScore W2003774034C2781014771 @default.
- W2003774034 hasConceptScore W2003774034C41625074 @default.
- W2003774034 hasConceptScore W2003774034C519063684 @default.
- W2003774034 hasConceptScore W2003774034C55493867 @default.
- W2003774034 hasConceptScore W2003774034C57409179 @default.
- W2003774034 hasConceptScore W2003774034C79879829 @default.
- W2003774034 hasConceptScore W2003774034C86803240 @default.
- W2003774034 hasIssue "2" @default.
- W2003774034 hasLocation W20037740341 @default.
- W2003774034 hasLocation W20037740342 @default.
- W2003774034 hasOpenAccess W2003774034 @default.
- W2003774034 hasPrimaryLocation W20037740341 @default.
- W2003774034 hasRelatedWork W1976658853 @default.
- W2003774034 hasRelatedWork W1988162406 @default.
- W2003774034 hasRelatedWork W1996394259 @default.
- W2003774034 hasRelatedWork W2003774034 @default.
- W2003774034 hasRelatedWork W2032644101 @default.
- W2003774034 hasRelatedWork W2045209097 @default.
- W2003774034 hasRelatedWork W2048839339 @default.
- W2003774034 hasRelatedWork W2060291827 @default.
- W2003774034 hasRelatedWork W2071537326 @default.
- W2003774034 hasRelatedWork W2317764201 @default.
- W2003774034 hasVolume "56" @default.
- W2003774034 isParatext "false" @default.
- W2003774034 isRetracted "false" @default.
- W2003774034 magId "2003774034" @default.
- W2003774034 workType "article" @default.