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• W2003789953 endingPage "946" @default.
• W2003789953 startingPage "941" @default.
• W2003789953 abstract "The effect of long-term (12 weeks) oral treatment with sodium orthovanadate on hepatic glycogen metabolizing and lipogenic enzymes was studied in genetically diabetic mice. These mice were characterized by significant (P < .001) obesity, hyperglycemia, and hyperinsulinemia. Vanadate administration led to significant decreases in body weight (P < .001) and plasma insulin levels (P < .01) and the mice became normoglycemic. The total glycogen synthase (EC 2.4.1.11) activity in the livers of diabetic mice showed a 47% increase, which did not undergo any significant change after treatment with vanadate. Hepatic phosphorylase (EC 2.4.1.1) activities (a and total) showed twofold increases in mice when compared with the nondiabetic ones. Vanadate caused significant decreases in phosphorylase a (P < .02) and total phosphorylase (P < .001) activities. Glucose-6-phosphate dehydrogenase (EC 1.1.1.49) and malic enzyme (EC 1.1.1.40) in diabetic liver had differential alterations, as indicated by a 50% decrease in glucose-6-phosphate dehydrogenase and 160% increase in malic enzyme activities. Vanadate administration led to normalization of both enzyme activities. In nondiabetic mice, vanadate treatment did not cause changes in any parameter, except for a 46% decrease in plasma insulin levels. This investigation indicates that vanadate can normalize many of the metabolic abnormalities seen in the liver of genetically diabetic mice, a model for non-insulin-dependent diabetes mellitus (NIDDM). Vanadate also causes a decrease in plasma insulin level, along with normalization of plasma glucose, which suggests a partial reversal of insulin resistance." @default.
• W2003789953 created "2016-06-24" @default.
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• W2003789953 date "1991-09-01" @default.
• W2003789953 modified "2023-09-30" @default.
• W2003789953 title "Long-term effects of vanadate treatment on glycogen metabolizing and lipogenic enzymes of liver in genetically diabetic () mice" @default.
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• W2003789953 doi "https://doi.org/10.1016/0026-0495(91)90070-d" @default.
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• W2003789953 hasPublicationYear "1991" @default.
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