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• W2003790210 abstract "In the decade following their initial discovery, the suppressor of cytokine signaling (SOCS) proteins have been studied for their potential use as immunomodulators in disease. SOCS proteins, especially SOCS1 and SOCS3, are expressed by immune cells and cells of the central nervous system (CNS) and have the potential to impact immune processes within the CNS, including inflammatory cytokine and chemokine production, activation of microglia, macrophages and astrocytes, immune cell infiltration and autoimmunity. We describe CNS-relevant <i>in vitro</i> and <i>in vivo</i> studies that have examined the function of SOCS1 or SOCS3 under various neuroinflammatory or neuropathological conditions, including exposure of CNS cells to inflammatory cytokines or bacterial infection, demyelinating insults, stroke, spinal cord injury, multiple sclerosis and glioblastoma multiforme." @default.
• W2003790210 created "2016-06-24" @default.
• W2003790210 creator A5005333528 @default.
• W2003790210 creator A5032782967 @default.
• W2003790210 creator A5055816174 @default.
• W2003790210 date "2009-08-01" @default.
• W2003790210 modified "2023-10-13" @default.
• W2003790210 title "SOCS1 and SOCS3 in the control of CNS immunity" @default.
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• W2003790210 doi "https://doi.org/10.1016/j.it.2009.07.001" @default.
• W2003790210 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2836122" @default.
• W2003790210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19643666" @default.
• W2003790210 hasPublicationYear "2009" @default.
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