FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003792955> ?p ?o ?g. }

• W2003792955 endingPage "329" @default.
• W2003792955 startingPage "319" @default.
• W2003792955 abstract "Our recent studies with lactacystin, a prototype proteasome inhibitor, have suggested that the proteasome is a key regulator of LPS-induced signaling pathways contributing to the inflammatory process. Moreover, lactacystin protects animals from LPS-induced shock. Therefore, we sought to identify other less toxic compounds that would block the chymotrypsin-like activity of the proteasome or LPS-induced nitric oxide (NO). After screening over 100 natural compounds (based on chemistry and inhibition of LPS-induced biological activities), we now report for the first time that quercetin, like lactacystin (the prototype proteasome inhibitor), and mevinolin are also inhibitors of the chymotrypsin-like activity of the cellular proteasome within living cells. In addition, this study also suggests that mevinolin and quercetin both have relatively potent anti-inflammatory effects on LPS-treated macrophages in vitro. Interestingly, both of these compounds behave like lactacystin in that they block LPS-induced NO to a greater extent than TNF-alpha. The results of our experiments clearly suggest that mevinolin, in combination with the antibiotic imipenem, can provide protection against polymicrobial septic lethality induced by cecal-ligation and puncture in mice. Collectively, these studies strongly support the conclusion that therapeutic targeting of cellular proteasomes, in conjunction with standard antimicrobial therapy, may be of considerable survival benefit in the treatment of septic shock." @default.
• W2003792955 created "2016-06-24" @default.
• W2003792955 creator A5004239757 @default.
• W2003792955 creator A5005348281 @default.
• W2003792955 creator A5011330394 @default.
• W2003792955 creator A5027202086 @default.
• W2003792955 creator A5041046556 @default.
• W2003792955 creator A5043407838 @default.
• W2003792955 creator A5055298886 @default.
• W2003792955 creator A5076081554 @default.
• W2003792955 creator A5084040073 @default.
• W2003792955 date "2008-10-01" @default.
• W2003792955 modified "2023-10-12" @default.
• W2003792955 title "A combination of proteasome inhibitors and antibiotics prevents lethality in a septic shock model" @default.
• W2003792955 cites W1507185750 @default.
• W2003792955 cites W1513161963 @default.
• W2003792955 cites W1525331105 @default.
• W2003792955 cites W1586717843 @default.
• W2003792955 cites W1603688682 @default.
• W2003792955 cites W1629179716 @default.
• W2003792955 cites W1829424989 @default.
• W2003792955 cites W1894983492 @default.
• W2003792955 cites W1897919101 @default.
• W2003792955 cites W1966901487 @default.
• W2003792955 cites W1968145787 @default.
• W2003792955 cites W1968942653 @default.
• W2003792955 cites W1970868418 @default.
• W2003792955 cites W1971992269 @default.
• W2003792955 cites W1982932317 @default.
• W2003792955 cites W1988620153 @default.
• W2003792955 cites W1994076669 @default.
• W2003792955 cites W1994882932 @default.
• W2003792955 cites W1995046784 @default.
• W2003792955 cites W2003809286 @default.
• W2003792955 cites W2003896508 @default.
• W2003792955 cites W2017885661 @default.
• W2003792955 cites W2021314070 @default.
• W2003792955 cites W2026236749 @default.
• W2003792955 cites W2031202586 @default.
• W2003792955 cites W2038515975 @default.
• W2003792955 cites W2049327206 @default.
• W2003792955 cites W2050392973 @default.
• W2003792955 cites W2072768552 @default.
• W2003792955 cites W2084744450 @default.
• W2003792955 cites W2089308595 @default.
• W2003792955 cites W2093944336 @default.
• W2003792955 cites W2114839157 @default.
• W2003792955 cites W2121585887 @default.
• W2003792955 cites W2135720956 @default.
• W2003792955 cites W2136912731 @default.
• W2003792955 cites W2148599087 @default.
• W2003792955 cites W2151274898 @default.
• W2003792955 cites W2322598508 @default.
• W2003792955 cites W2342661706 @default.
• W2003792955 cites W2417372968 @default.
• W2003792955 cites W2497022161 @default.
• W2003792955 doi "https://doi.org/10.1177/1753425908096855" @default.
• W2003792955 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2666041" @default.
• W2003792955 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18809656" @default.
• W2003792955 hasPublicationYear "2008" @default.
• W2003792955 type Work @default.
• W2003792955 sameAs 2003792955 @default.
• W2003792955 citedByCount "27" @default.
• W2003792955 countsByYear W20037929552012 @default.
• W2003792955 countsByYear W20037929552014 @default.
• W2003792955 countsByYear W20037929552015 @default.
• W2003792955 countsByYear W20037929552017 @default.
• W2003792955 countsByYear W20037929552018 @default.
• W2003792955 countsByYear W20037929552021 @default.
• W2003792955 countsByYear W20037929552022 @default.
• W2003792955 countsByYear W20037929552023 @default.
• W2003792955 crossrefType "journal-article" @default.
• W2003792955 hasAuthorship W2003792955A5004239757 @default.
• W2003792955 hasAuthorship W2003792955A5005348281 @default.
• W2003792955 hasAuthorship W2003792955A5011330394 @default.
• W2003792955 hasAuthorship W2003792955A5027202086 @default.
• W2003792955 hasAuthorship W2003792955A5041046556 @default.
• W2003792955 hasAuthorship W2003792955A5043407838 @default.
• W2003792955 hasAuthorship W2003792955A5055298886 @default.
• W2003792955 hasAuthorship W2003792955A5076081554 @default.
• W2003792955 hasAuthorship W2003792955A5084040073 @default.
• W2003792955 hasBestOaLocation W20037929552 @default.
• W2003792955 hasConcept C185592680 @default.
• W2003792955 hasConcept C203014093 @default.
• W2003792955 hasConcept C27740335 @default.
• W2003792955 hasConcept C2776148510 @default.
• W2003792955 hasConcept C2777628635 @default.
• W2003792955 hasConcept C2778367456 @default.
• W2003792955 hasConcept C2778384902 @default.
• W2003792955 hasConcept C55493867 @default.
• W2003792955 hasConcept C86803240 @default.
• W2003792955 hasConcept C98274493 @default.
• W2003792955 hasConceptScore W2003792955C185592680 @default.
• W2003792955 hasConceptScore W2003792955C203014093 @default.
• W2003792955 hasConceptScore W2003792955C27740335 @default.
• W2003792955 hasConceptScore W2003792955C2776148510 @default.
• W2003792955 hasConceptScore W2003792955C2777628635 @default.
• W2003792955 hasConceptScore W2003792955C2778367456 @default.

• next