FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003795492> ?p ?o ?g. }

• W2003795492 endingPage "1144" @default.
• W2003795492 startingPage "1137" @default.
• W2003795492 abstract "Hydrophobins are small surface active proteins that fulfil a wide spectrum of functions in fungal growth and development. The human fungal pathogen Aspergillus fumigatus expresses RodA hydrophobins that self-assemble on the outer conidial surface into tightly organized nanorods known as rodlets. AFM investigation of the conidial surface allows us to evidence that RodA hydrophobins self-assemble into rodlets through bilayers. Within bilayers, hydrophilic domains of hydrophobins point inward, thus making a hydrophilic core, while hydrophobic domains point outward. AFM measurements reveal that several rodlet bilayers are present on the conidial surface thus showing that proteins self-assemble into a complex three-dimensional multilayer system. The self-assembly of RodA hydrophobins into rodlets results from attractive interactions between stacked β-sheets, which conduct to a final linear cross-β spine structure. A Monte Carlo simulation shows that anisotropic interactions are the main driving forces leading the hydrophobins to self-assemble into parallel rodlets, which are further structured in nanodomains. Taken together, these findings allow us to propose a mechanism, which conducts RodA hydrophobins to a highly ordered rodlet structure. The mechanism of hydrophobin assembly into rodlets offers new prospects for the development of more efficient strategies leading to disruption of rodlet formation allowing a rapid detection of the fungus by the immune system." @default.
• W2003795492 created "2016-06-24" @default.
• W2003795492 creator A5019410436 @default.
• W2003795492 creator A5031718132 @default.
• W2003795492 creator A5059237710 @default.
• W2003795492 creator A5064172787 @default.
• W2003795492 creator A5072206241 @default.
• W2003795492 date "2014-06-01" @default.
• W2003795492 modified "2023-10-16" @default.
• W2003795492 title "Self-assembly of proteins into a three-dimensional multilayer system: Investigation of the surface of the human fungal pathogen Aspergillus fumigatus" @default.
• W2003795492 cites W1502349316 @default.
• W2003795492 cites W1964043565 @default.
• W2003795492 cites W1966487136 @default.
• W2003795492 cites W1970865115 @default.
• W2003795492 cites W1972261075 @default.
• W2003795492 cites W1974187431 @default.
• W2003795492 cites W1976369273 @default.
• W2003795492 cites W2005266047 @default.
• W2003795492 cites W2012519802 @default.
• W2003795492 cites W2012902348 @default.
• W2003795492 cites W2014440750 @default.
• W2003795492 cites W2018967072 @default.
• W2003795492 cites W2023724685 @default.
• W2003795492 cites W2043148416 @default.
• W2003795492 cites W2046834375 @default.
• W2003795492 cites W2046914679 @default.
• W2003795492 cites W2071097156 @default.
• W2003795492 cites W2071466044 @default.
• W2003795492 cites W2074496652 @default.
• W2003795492 cites W2082146295 @default.
• W2003795492 cites W2093098257 @default.
• W2003795492 cites W2094245023 @default.
• W2003795492 cites W2094530284 @default.
• W2003795492 cites W2096472007 @default.
• W2003795492 cites W2099176294 @default.
• W2003795492 cites W2103758980 @default.
• W2003795492 cites W2106551616 @default.
• W2003795492 cites W2115591740 @default.
• W2003795492 cites W2129507901 @default.
• W2003795492 cites W2138738780 @default.
• W2003795492 cites W2143674465 @default.
• W2003795492 cites W2143814233 @default.
• W2003795492 cites W2143986369 @default.
• W2003795492 cites W2145010634 @default.
• W2003795492 cites W2150227948 @default.
• W2003795492 cites W2153911335 @default.
• W2003795492 cites W2163210644 @default.
• W2003795492 cites W2171777893 @default.
• W2003795492 cites W2334103819 @default.
• W2003795492 cites W2335171682 @default.
• W2003795492 cites W3104854458 @default.
• W2003795492 cites W3105080255 @default.
• W2003795492 cites W2002455220 @default.
• W2003795492 doi "https://doi.org/10.1016/j.bbapap.2014.03.001" @default.
• W2003795492 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24631542" @default.
• W2003795492 hasPublicationYear "2014" @default.
• W2003795492 type Work @default.
• W2003795492 sameAs 2003795492 @default.
• W2003795492 citedByCount "16" @default.
• W2003795492 countsByYear W20037954922014 @default.
• W2003795492 countsByYear W20037954922015 @default.
• W2003795492 countsByYear W20037954922016 @default.
• W2003795492 countsByYear W20037954922017 @default.
• W2003795492 countsByYear W20037954922018 @default.
• W2003795492 countsByYear W20037954922019 @default.
• W2003795492 countsByYear W20037954922022 @default.
• W2003795492 countsByYear W20037954922023 @default.
• W2003795492 crossrefType "journal-article" @default.
• W2003795492 hasAuthorship W2003795492A5019410436 @default.
• W2003795492 hasAuthorship W2003795492A5031718132 @default.
• W2003795492 hasAuthorship W2003795492A5059237710 @default.
• W2003795492 hasAuthorship W2003795492A5064172787 @default.
• W2003795492 hasAuthorship W2003795492A5072206241 @default.
• W2003795492 hasConcept C104317684 @default.
• W2003795492 hasConcept C12554922 @default.
• W2003795492 hasConcept C171250308 @default.
• W2003795492 hasConcept C192562407 @default.
• W2003795492 hasConcept C2778104808 @default.
• W2003795492 hasConcept C2779787849 @default.
• W2003795492 hasConcept C55493867 @default.
• W2003795492 hasConcept C86803240 @default.
• W2003795492 hasConcept C89423630 @default.
• W2003795492 hasConceptScore W2003795492C104317684 @default.
• W2003795492 hasConceptScore W2003795492C12554922 @default.
• W2003795492 hasConceptScore W2003795492C171250308 @default.
• W2003795492 hasConceptScore W2003795492C192562407 @default.
• W2003795492 hasConceptScore W2003795492C2778104808 @default.
• W2003795492 hasConceptScore W2003795492C2779787849 @default.
• W2003795492 hasConceptScore W2003795492C55493867 @default.
• W2003795492 hasConceptScore W2003795492C86803240 @default.
• W2003795492 hasConceptScore W2003795492C89423630 @default.
• W2003795492 hasIssue "6" @default.
• W2003795492 hasLocation W20037954921 @default.
• W2003795492 hasLocation W20037954922 @default.
• W2003795492 hasLocation W20037954923 @default.
• W2003795492 hasLocation W20037954924 @default.
• W2003795492 hasOpenAccess W2003795492 @default.
• W2003795492 hasPrimaryLocation W20037954921 @default.

• next