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- W2003802600 abstract "Abstract: Increasing concentrations of calcium in the Ringer solution, [Ca++]o, increased the rate and amplitude of contractions of spontaneously beating, isolated rat atria. Nifedipine 100 μg/l had negative chronotropic and inotropic effects when [Ca++]o was 2.0 and 5.0 meq./l, and atrial arrest occurred in some experiments at these calcium concentrations. The sinus node recovery time decreased with increasing [Ca++]o, but was increased by nifedipine 100 μg/l. All the effects of nifedipine were most pronounced at the lowest [Ca++]o studied (2.0 meq./l), while these effects were negligible at the highest [Ca++]o used (8.0 meq./l). Nifedipine 100 μg/l did not influence the threshold for electricall) induced atrial fibrillation. However, pretreatment with the drug completely protected the atria against calcium-induced arrhythmias. It is concluded that the anti-arrhythmic activity of nifedipine is due to its calcium-antagonistic effect." @default.
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- W2003802600 date "2009-03-13" @default.
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- W2003802600 title "Calcium-antagonistic and Anti-arrhythmic Effects of Nifedipine on the Isolated Rat Atrium" @default.
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- W2003802600 doi "https://doi.org/10.1111/j.1600-0773.1975.tb00856.x" @default.
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