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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003803262> ?p ?o ?g. }

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• W2003803262 abstract "Screening of the in-house sample collection for compounds with HCV NS5B RNA dependent RNA polymerase inhibition led to the identification of a new lead. Afterwards, we discovered that the screening lead, rather than containing the expected structure 1, was comprised of roughly a 1:1 mixture of meconic acid 2 and its monoethyl ester 3, with all inhibitory potency residing with 3. We propose that this compound shares critical common features for activity with α,γ-diketoacids inhibitors previously discovered by our group. SAR around this molecule will be presented to provide an improved basis for structure-based ligand design." @default.
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• W2003803262 date "2004-06-01" @default.
• W2003803262 modified "2023-10-16" @default.
• W2003803262 title "The monoethyl ester of meconic acid is an active site inhibitor of HCV NS5B RNA-dependent RNA polymerase" @default.
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• W2003803262 doi "https://doi.org/10.1016/j.bmcl.2004.03.087" @default.
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