Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003804173> ?p ?o ?g. }
- W2003804173 endingPage "439" @default.
- W2003804173 startingPage "422" @default.
- W2003804173 abstract "The purpose of this study was to investigate the inhibitory mechanism of colchicine on the osteoclastic bone resorption. Male Wistar rats, weighting 120g on average, were injected intravenously with colchicine at the dose of 1.0 mg/kg. The control rats were injected with physiological saline. They were sacrificed at 1, 2, 4 and 8 hours after the injection. Osteoclasts located in the proximal metaphysis of tibia were examined with an electron microscope. Some specimens were stained for acid phosphatase. After the colchicine injection, the number of microtubules in the cytoplasm decreased and the Golgi apparatus moved from the circumunclear area and spread throughout the cytoplasm. Acid phosphatase-positive trans Golgi network became difficult to detect in the dislocated Golgi apparatus. In the central area of the cell, clusters of small vacuoles and vesicles which contained various quantities of amorphous material appeared. Acid phosphatase activity was detected in these vacuoles and vesicles. The structure of the ruffled border was disturbed. In the organ culture of mouse calvaria, colchicine inhibited PTH-enhanced bone resorption and the release of β-glucuronidase and acid phosphatase dose dependently. The results obtained in this study suggested that the disturbance of microtubules by colchicine causes a functional inhibition of both the Golgi-lysosomal system and the ruffled border and subsequently reduces the bone resorbing activity of osteoclasts." @default.
- W2003804173 created "2016-06-24" @default.
- W2003804173 creator A5080994194 @default.
- W2003804173 date "1990-01-01" @default.
- W2003804173 modified "2023-10-16" @default.
- W2003804173 title "Effect of colchicine on the Golgi apparatus and the lysosmal system in osteoclasts." @default.
- W2003804173 cites W149466162 @default.
- W2003804173 cites W1965316807 @default.
- W2003804173 cites W1980429073 @default.
- W2003804173 cites W1986740378 @default.
- W2003804173 cites W1990834162 @default.
- W2003804173 cites W1996514721 @default.
- W2003804173 cites W2007799995 @default.
- W2003804173 cites W2008190738 @default.
- W2003804173 cites W2008814134 @default.
- W2003804173 cites W2017047412 @default.
- W2003804173 cites W2017544009 @default.
- W2003804173 cites W2020414223 @default.
- W2003804173 cites W2020678904 @default.
- W2003804173 cites W2028693092 @default.
- W2003804173 cites W2030548078 @default.
- W2003804173 cites W2035360203 @default.
- W2003804173 cites W2035419580 @default.
- W2003804173 cites W2050042876 @default.
- W2003804173 cites W2054761003 @default.
- W2003804173 cites W2057762926 @default.
- W2003804173 cites W2071789541 @default.
- W2003804173 cites W2072461078 @default.
- W2003804173 cites W2075356469 @default.
- W2003804173 cites W2083491606 @default.
- W2003804173 cites W2090447324 @default.
- W2003804173 cites W2117508280 @default.
- W2003804173 cites W2125111589 @default.
- W2003804173 cites W2131796461 @default.
- W2003804173 cites W2132433230 @default.
- W2003804173 cites W2133591889 @default.
- W2003804173 cites W2138187435 @default.
- W2003804173 cites W2139090888 @default.
- W2003804173 cites W2139313036 @default.
- W2003804173 cites W2160685946 @default.
- W2003804173 cites W2166549790 @default.
- W2003804173 cites W2172149249 @default.
- W2003804173 cites W2243887288 @default.
- W2003804173 cites W2401776855 @default.
- W2003804173 cites W2405981081 @default.
- W2003804173 cites W2409025637 @default.
- W2003804173 cites W2415121098 @default.
- W2003804173 cites W2416153779 @default.
- W2003804173 cites W2462849422 @default.
- W2003804173 cites W3215720982 @default.
- W2003804173 cites W988514046 @default.
- W2003804173 doi "https://doi.org/10.2330/joralbiosci1965.32.422" @default.
- W2003804173 hasPublicationYear "1990" @default.
- W2003804173 type Work @default.
- W2003804173 sameAs 2003804173 @default.
- W2003804173 citedByCount "3" @default.
- W2003804173 countsByYear W20038041732022 @default.
- W2003804173 countsByYear W20038041732023 @default.
- W2003804173 crossrefType "journal-article" @default.
- W2003804173 hasAuthorship W2003804173A5080994194 @default.
- W2003804173 hasBestOaLocation W20038041731 @default.
- W2003804173 hasConcept C102568950 @default.
- W2003804173 hasConcept C119062480 @default.
- W2003804173 hasConcept C126322002 @default.
- W2003804173 hasConcept C130316041 @default.
- W2003804173 hasConcept C134018914 @default.
- W2003804173 hasConcept C146562846 @default.
- W2003804173 hasConcept C158617107 @default.
- W2003804173 hasConcept C181199279 @default.
- W2003804173 hasConcept C185592680 @default.
- W2003804173 hasConcept C190062978 @default.
- W2003804173 hasConcept C20418707 @default.
- W2003804173 hasConcept C21547065 @default.
- W2003804173 hasConcept C2776636253 @default.
- W2003804173 hasConcept C41625074 @default.
- W2003804173 hasConcept C55493867 @default.
- W2003804173 hasConcept C673006 @default.
- W2003804173 hasConcept C71924100 @default.
- W2003804173 hasConcept C86803240 @default.
- W2003804173 hasConcept C95444343 @default.
- W2003804173 hasConceptScore W2003804173C102568950 @default.
- W2003804173 hasConceptScore W2003804173C119062480 @default.
- W2003804173 hasConceptScore W2003804173C126322002 @default.
- W2003804173 hasConceptScore W2003804173C130316041 @default.
- W2003804173 hasConceptScore W2003804173C134018914 @default.
- W2003804173 hasConceptScore W2003804173C146562846 @default.
- W2003804173 hasConceptScore W2003804173C158617107 @default.
- W2003804173 hasConceptScore W2003804173C181199279 @default.
- W2003804173 hasConceptScore W2003804173C185592680 @default.
- W2003804173 hasConceptScore W2003804173C190062978 @default.
- W2003804173 hasConceptScore W2003804173C20418707 @default.
- W2003804173 hasConceptScore W2003804173C21547065 @default.
- W2003804173 hasConceptScore W2003804173C2776636253 @default.
- W2003804173 hasConceptScore W2003804173C41625074 @default.
- W2003804173 hasConceptScore W2003804173C55493867 @default.
- W2003804173 hasConceptScore W2003804173C673006 @default.
- W2003804173 hasConceptScore W2003804173C71924100 @default.
- W2003804173 hasConceptScore W2003804173C86803240 @default.